Metformin


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2690 Functionally related protein(s)
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Protein Name
UniProt Entry
Gene Symbol
Organism
NCBI Gene ID
# All related compound(s)
#Article(s)
1 insulin INS_HUMAN INS Homo sapiens 3630 7950 1675
2 mechanistic target of rapamycin kinase MTOR_HUMAN MTOR Homo sapiens 2475 3411 361
3 protein kinase AMP-activated catalytic subunit alpha 2 AAPK2_HUMAN PRKAA2 Homo sapiens 5563 919 339
4 protein kinase AMP-activated catalytic subunit alpha 1 AAPK1_HUMAN PRKAA1 Homo sapiens 5562 812 210
5 dipeptidyl peptidase 4 DPP4_HUMAN DPP4 Homo sapiens 1803 1201 176
6 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 169
7 protein kinase AMP-activated catalytic subunit alpha 2 AAPK2_RAT Prkaa2 Rattus norvegicus 78975 753 160
8 solute carrier family 22 member 1 S22A1_HUMAN SLC22A1 Homo sapiens 6580 415 116
9 solute carrier family 5 member 2 SC5A2_HUMAN SLC5A2 Homo sapiens 6524 363 95
10 protein kinase AMP-activated non-catalytic subunit beta 1 AAKB1_HUMAN PRKAB1 Homo sapiens 5564 368 89
11 tumor necrosis factor TNFA_HUMAN TNF Homo sapiens 7124 8006 87
12 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 81
13 glucagon like peptide 1 receptor GLP1R_HUMAN GLP1R Homo sapiens 2740 485 77
14 hemoglobin subunit alpha 1 HBA_HUMAN HBA1 Homo sapiens 3039 451 73
15 interleukin 6 IL6_HUMAN IL6 Homo sapiens 3569 5444 71
16 CREB regulated transcription coactivator 1 CRTC1_MOUSE Crtc1 Mus musculus 382056 993 69
17 glucagon GLUC_HUMAN GCG Homo sapiens 2641 671 65
18 C-reactive protein CRP_HUMAN CRP Homo sapiens 1401 2285 63
19 serine/threonine kinase 11 STK11_HUMAN STK11 Homo sapiens 6794 365 60
20 solute carrier family 47 member 1 S47A1_HUMAN SLC47A1 Homo sapiens 55244 185 58
21 insulin like growth factor 1 IGF1_HUMAN IGF1 Homo sapiens 3479 1917 54
22 adiponectin, C1Q and collagen domain containing ADIPO_HUMAN ADIPOQ Homo sapiens 9370 1074 54
23 NADH:ubiquinone oxidoreductase subunit B3 NDUB3_HUMAN NDUFB3 Homo sapiens 4709 539 54
24 mitogen-activated protein kinase 1 MK01_HUMAN MAPK1 Homo sapiens 5594 4181 54
25 solute carrier family 22 member 2 S22A2_HUMAN SLC22A2 Homo sapiens 6582 255 52
26 epidermal growth factor receptor EGFR_HUMAN EGFR Homo sapiens 1956 4580 51
27 hypoxia inducible factor 1 subunit alpha HIF1A_HUMAN HIF1A Homo sapiens 3091 2152 51
28 signal transducer and activator of transcription 3 STAT3_HUMAN STAT3 Homo sapiens 6774 2503 49
29 BCL2 apoptosis regulator BCL2_HUMAN BCL2 Homo sapiens 596 4403 49
30 mechanistic target of rapamycin kinase MTOR_MOUSE Mtor Mus musculus 56717 1120 49
31 transforming growth factor beta 1 TGFB1_HUMAN TGFB1 Homo sapiens 7040 2953 47
32 caspase 3 CASP3_HUMAN CASP3 Homo sapiens 836 5209 44
33 SAFB like transcription modulator SLTM_HUMAN SLTM Homo sapiens 79811 394 42
34 tumor necrosis factor TNFA_RAT Tnf Rattus norvegicus 24835 3922 42
35 tumor necrosis factor TNFA_MOUSE Tnf Mus musculus 21926 5931 42
36 ribosomal protein S6 kinase B1 KS6B1_HUMAN RPS6KB1 Homo sapiens 6198 764 41
37 thymoma viral proto-oncogene 1 AKT1_MOUSE Akt1 Mus musculus 11651 3034 40
38 erb-b2 receptor tyrosine kinase 2 ERBB2_HUMAN ERBB2 Homo sapiens 2064 2723 40
39 serpin family E member 1 PAI1_HUMAN SERPINE1 Homo sapiens 5054 1182 39
40 cyclin D1 CCND1_HUMAN CCND1 Homo sapiens 595 1747 38
41 nuclear factor kappa B subunit 1 NFKB1_HUMAN NFKB1 Homo sapiens 4790 4834 38
42 interleukin 6 IL6_MOUSE Il6 Mus musculus 16193 3985 36
43 insulin like growth factor 1 receptor IGF1R_HUMAN IGF1R Homo sapiens 3480 814 36
44 sirtuin 1 SIR1_HUMAN SIRT1 Homo sapiens 23411 1253 36
45 mitogen-activated protein kinase 3 MK03_HUMAN MAPK3 Homo sapiens 5595 3238 35
46 MYC proto-oncogene, bHLH transcription factor MYC_HUMAN MYC Homo sapiens 4609 2261 34
47 vascular endothelial growth factor A VEGFA_HUMAN VEGFA Homo sapiens 7422 4023 34
48 sex hormone binding globulin SHBG_HUMAN SHBG Homo sapiens 6462 621 32
49 matrix metallopeptidase 9 MMP9_HUMAN MMP9 Homo sapiens 4318 2470 31
50 NFE2 like bZIP transcription factor 2 NF2L2_HUMAN NFE2L2 Homo sapiens 4780 2545 31