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34139918 | Multidimensional mechanisms of metformin in cancer treatment. | 2022 Apr |
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34637881 | Antiproliferative effects of metformin in cellular models of pheochromocytoma. | 2022 Jan 1 |
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| 3 |
35072253 | Metformin in selected malignancies in women. | 2022 Jan 24 |
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| 4 |
32951587 | The Chemosensitizing Role of Metformin in Anti-Cancer Therapy. | 2021 |
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| 5 |
33025801 | The Effect of Body Mass Index and Metformin on Matrix Gene Expression in Arthritic Primary Human Chondrocytes. | 2021 Dec |
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| 6 |
33262823 | Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1α/PKM2/STAT3 pathway. | 2021 Jan |
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33752282 | Hypoxia-Induced Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Is Regulated by Caveolin-1-Dependent Adenosine Monophosphate-Activated Protein Kinase Activity. | 2021 Jun |
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| 8 |
34123772 | Combination of Metformin, Sodium Oxamate and Doxorubicin Induces Apoptosis and Autophagy in Colorectal Cancer Cells via Downregulation HIF-1α. | 2021 |
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| 9 |
34478236 | EVT-701 is a novel selective and safe mitochondrial complex 1 inhibitor with potent anti-tumor activity in models of solid cancers. | 2021 Oct |
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| 10 |
34548527 | Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism. | 2021 Sep 21 |
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| 11 |
34736121 | Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro. | 2021 Oct 19 |
3 |
| 12 |
31963541 | Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1α for Lung Tumorigenesis. | 2020 Jan 17 |
3 |
| 13 |
32592239 | Metformin suppresses HIF-1α expression in cancer-associated fibroblasts to prevent tumor-stromal cross talk in breast cancer. | 2020 Aug |
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| 14 |
32641388 | Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4+ T Cell Effector Functions and Activation-Induced Metabolic Reprogramming. | 2020 Aug 15 |
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| 15 |
32715434 | Influence of metformin on HIF-1 pathway in multiple myeloma. | 2020 Oct |
5 |
| 16 |
30019648 | Metformin one in a Million Efficient Medicines for Rheumatoid Arthritis Complications: Inflammation, Osteoblastogenesis, Cardiovascular Disease, Malignancies. | 2019 |
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| 17 |
30334569 | Metformin inhibits mTOR-HIF-1α axis and profibrogenic and inflammatory biomarkers in thioacetamide-induced hepatic tissue alterations. | 2019 Jun |
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| 18 |
30655321 | SPHK1 Is a Novel Target of Metformin in Ovarian Cancer. | 2019 Apr |
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| 19 |
30728892 | A Nonsense Mitochondrial DNA Mutation Associates with Dysfunction of HIF1α in a Von Hippel-Lindau Renal Oncocytoma. | 2019 |
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| 20 |
30784061 | Inactivating the ubiquitin ligase Parkin suppresses cell proliferation and induces apoptosis in human keloids. | 2019 Feb 19 |
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| 21 |
30909494 | Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines. | 2019 Mar 22 |
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| 22 |
31002375 | [Corrigendum] Metformin suppresses hypoxia‑induced migration via the HIF‑1α/VEGF pathway in gallbladder cancer in vitro and in vivo. | 2019 Jun |
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| 23 |
31012989 | Metformin may offer no protective effect in men undergoing external beam radiation therapy for prostate cancer. | 2019 May |
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| 24 |
31324361 | Metformin Associated With Increased Survival in Type 2 Diabetes Patients With Pancreatic Cancer and Lymphoma. | 2019 Sep |
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| 25 |
31341409 | Metformin Inhibits Epithelial-to-Mesenchymal Transition of Keloid Fibroblasts via the HIF-1α/PKM2 Signaling Pathway. | 2019 |
3 |
| 26 |
31626790 | Metformin attenuates hepatoma cell proliferation by decreasing glycolytic flux through the HIF-1α/PFKFB3/PFK1 pathway. | 2019 Dec 15 |
3 |
| 27 |
31851935 | Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk. | 2019 Dec 17 |
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| 28 |
29662316 | Metformin inhibits proliferation and cytotoxicity and induces apoptosis via AMPK pathway in CD19-chimeric antigen receptor-modified T cells. | 2018 |
2 |
| 29 |
29958416 | Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines. | 2018 Jun 28 |
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| 30 |
30217067 | Hyperglycemia-Associated Dysregulation of O-GlcNAcylation and HIF1A Reduces Anticancer Action of Metformin in Ovarian Cancer Cells (SKOV-3). | 2018 Sep 13 |
3 |
| 31 |
30272364 | Metformin suppresses hypoxia‑induced migration via the HIF‑1α/VEGF pathway in gallbladder cancer in vitro and in vivo. | 2018 Dec |
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| 32 |
28161619 | Combination of metformin with chemotherapeutic drugs via different molecular mechanisms. | 2017 Mar |
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| 33 |
28233769 | Erratum: Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis. | 2017 Feb 24 |
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| 34 |
29088755 | Suppression of hypoxia-induced excessive angiogenesis by metformin via elevating tumor blood perfusion. | 2017 Sep 26 |
2 |
| 35 |
26616058 | Targeting HIF-1α is a prerequisite for cell sensitivity to dichloroacetate (DCA) and metformin. | 2016 Jan 8 |
2 |
| 36 |
26621849 | Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma. | 2016 Jan 5 |
2 |
| 37 |
27210058 | Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma. | 2016 Jul |
2 |
| 38 |
27474170 | Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma. | 2016 Aug 23 |
3 |
| 39 |
27762347 | Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis. | 2016 Oct 20 |
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| 40 |
25661368 | Metformin enhances radiation response of ECa109 cells through activation of ATM and AMPK. | 2015 Feb |
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| 41 |
25790097 | IGF1 regulates PKM2 function through Akt phosphorylation. | 2015 |
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| 42 |
26101707 | Metformin inhibits gastric cancer via the inhibition of HIF1α/PKM2 signaling. | 2015 |
3 |
| 43 |
26625311 | Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis. | 2015 Dec 29 |
3 |
| 44 |
24788596 | Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines. | 2014 Jun |
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| 45 |
24843020 | Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. | 2014 May 13 |
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| 46 |
25310259 | Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel‑7402/5‑fluorouracil cells. | 2014 Dec |
3 |
| 47 |
23589723 | Activation of AMP-Activated Protein Kinase α and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells. | 2013 |
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| 48 |
22643892 | Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC. | 2012 May 29 |
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| 49 |
23244125 | Use of oral antidiabetic drugs (metformin and pioglitazone) in diabetic patients with breast cancer: how does it effect serum Hif-1 alpha and 8Ohdg levels? | 2012 |
3 |
| 50 |
21282369 | Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism. | 2011 Mar |
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