Metformin

tumor protein p53 ; Homo sapiens







81 Article(s)
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1 35196199 Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E). 2022 Feb 23 3
2 32657143 Combination of Curcumin and Metformin Inhibits Cell Growth and Induces Apoptosis without Affecting the Cell Cycle in LNCaP Prostate Cancer Cell Line. 2021 1
3 33187870 Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients. 2021 Jan 1
4 33191800 Type 2 Diabetes Associated with Abnormal p53 Immunohistochemical Patterns in Colorectal Cancer. 2021 Jan 1
5 33236135 Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells. 2021 Jan 2
6 33350292 Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism 2021 Apr 30 4
7 33358075 Metformin as a radiosensitiser for pelvic malignancy: A systematic review of the literature. 2021 Jun 1
8 33915902 Metformin Inhibits the Urea Cycle and Reduces Putrescine Generation in Colorectal Cancer Cell Lines. 2021 Apr 1 2
9 34135572 Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating P53 and RAP2A in vitro and in vivo [Retraction]. 2021 1
10 34528900 Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells. 2021 Sep 16 5
11 34564972 Down regulation of tumour biomarkers in colon cancer cells with IRNA PFK-1 plus metformin. 2021 Jul-Aug 1
12 34638899 Metformin Affects Olaparib Sensitivity through Induction of Apoptosis in Epithelial Ovarian Cancer Cell Lines. 2021 Sep 29 1
13 34676202 Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells. 2021 1
14 32606605 Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo. 2020 4
15 32631421 Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression. 2020 Jul 6 1
16 32742376 TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents. 2020 Aug 1
17 32869837 Metformin inhibits the growth of ovarian cancer cells by promoting the Parkin-induced p53 ubiquitination. 2020 Sep 1 5
18 33051086 Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation. 2020 Nov 1
19 33149857 Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells. 2020 Oct 1
20 30710424 Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells. 2019 Apr 2
21 30866414 Integrin β1-Mediated Cell⁻Cell Adhesion Augments Metformin-Induced Anoikis. 2019 Mar 7 1
22 30936596 Induction of Apoptosis by a Combination of 2-Deoxyglucose and Metformin in Esophageal Squamous Cell Carcinoma by Targeting Cancer Cell Metabolism. 2019 Mar 3
23 31047842 Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells. 2019 Aug 2
24 31091555 Similarities and Distinctions in the Effects of Metformin and Carbon Monoxide in Immunometabolism. 2019 Apr 30 1
25 31114366 The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances. 2019 1
26 31244286 Metformin Modulates Cyclin D1 and P53 Expression to Inhibit Cell Proliferation and to Induce Apoptosis in Cervical Cancer Cell Lines. 2019 Jun 1 3
27 31258748 Role of p53 Family Proteins in Metformin Anti-Cancer Activities. 2019 2
28 31324361 Metformin Associated With Increased Survival in Type 2 Diabetes Patients With Pancreatic Cancer and Lymphoma. 2019 Sep 1
29 29185360 Role of metformin on base excision repair pathway in p53 wild-type H2009 and HepG2 cancer cells. 2018 Sep 2
30 29285650 Synergistic cytotoxicity of the dipeptidyl peptidase-IV inhibitor gemigliptin with metformin in thyroid carcinoma cells. 2018 Feb 1
31 29286156 Metformin-induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16. 2018 Mar 4
32 29334602 High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy. 2018 Oct 1
33 29423021 Association of p53 and mitochondrial gene with chemosensitization by metformin in ovarian cancer. 2018 Jan 9 2
34 29660403 ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response. 2018 Aug 1 2
35 30098371 Potential effects of metformin in DNA BER system based on oxidative status in type 2 diabetes. 2018 Nov 2
36 30442142 Metformin causes cancer cell death through downregulation of p53-dependent differentiated embryo chondrocyte 1. 2018 Nov 15 6
37 31508193 Efficacy of oral metformin in a patient with metastatic adrenocortical carcinoma: Examination of mechanisms and therapeutic implications. 2018 1
38 27128966 Metformin induces degradation of cyclin D1 via AMPK/GSK3β axis in ovarian cancer. 2017 Feb 1
39 27919208 Is Metformin a Therapeutic Paradigm for Colorectal Cancer: Insight into the Molecular Pathway? 2017 1
40 28052008 Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin. 2017 Jan 31 2
41 28193839 Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ΔNp63α Protein Expression and Inhibits Cancer Cell Viability. 2017 Mar 31 1
42 28464864 Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways. 2017 May 2 1
43 28618116 Differences in p53 status significantly influence the cellular response and cell survival to 1,25-dihydroxyvitamin D3-metformin cotreatment in colorectal cancer cells. 2017 Nov 1
44 28802253 The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer. 2017 Dec 1
45 28967197 Sugar-Coated Nanobullet: Growth Inhibition of Cancer Cells Induced by Metformin-Loaded Glyconanoparticles. 2017 Nov 22 1
46 29085821 Screening Novel Molecular Targets of Metformin in Breast Cancer by Proteomic Approach. 2017 1
47 29167573 Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production. 2017 Nov 22 1
48 26900800 Combining p53 stabilizers with metformin induces synergistic apoptosis through regulation of energy metabolism in castration-resistant prostate cancer. 2016 1
49 26956973 Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells. 2016 Feb 2
50 27109601 Combined metformin and resveratrol confers protection against UVC-induced DNA damage in A549 lung cancer cells via modulation of cell cycle checkpoints and DNA repair. 2016 Jun 2