Protein Name sirtuin 1
Organism Homo sapiens
Gene ID 23411
Gene Symbol


UniProt Q96EB6 (SIR1_HUMAN), A0A024QZQ1 (A0A024QZQ1_HUMAN), B0QZ35 (B0QZ35_HUMAN), E9PC49 (E9PC49_HUMAN), A8K128 (A8K128_HUMAN)
Relationships Total Number of functionally related compound(s) : 1253
Total Number of Articles : 3032

sirtuin 1

Gene Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

  • NAD-dependent protein deacetylase sirtuin-1
  • NAD-dependent protein deacylase sirtuin-1
  • SIR2-like protein 1
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