Protein Name tumor necrosis factor
Organism Rattus norvegicus
Gene ID 24835
Gene Symbol


UniProt P16599 (TNFA_RAT)
Relationships Total Number of functionally related compound(s) : 3922
Total Number of Articles : 10208

tumor necrosis factor

Gene Summary

Enables tumor necrosis factor receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of macromolecule metabolic process; and positive regulation of neuron death. Located in several cellular components, including external side of plasma membrane; extracellular space; and neuronal cell body. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including brain disease (multiple); congestive heart failure (multiple); inflammatory bowel disease (multiple); lung disease (multiple); and non-alcoholic fatty liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor). [provided by Alliance of Genome Resources, Apr 2022]

  • tumor necrosis factor
  • cachectin
  • tumor necrosis factor (TNF superfamily, member 2)
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