Protein Name interleukin 6
Organism Homo sapiens
Gene ID 3569
Gene Symbol


UniProt P05231 (IL6_HUMAN), Q75MH2 (Q75MH2_HUMAN), B5MC21 (B5MC21_HUMAN), B4DNQ5 (B4DNQ5_HUMAN), B4DVM1 (B4DVM1_HUMAN)
Relationships Total Number of functionally related compound(s) : 5444
Total Number of Articles : 13933

interleukin 6

Gene Summary

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]

  • interleukin-6
  • B-cell differentiation factor
  • B-cell stimulatory factor 2
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