Metformin

interleukin 6 ; Homo sapiens







71 Article(s)
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1 35605453 Metformin modulates mitochondrial function and mitophagy in peripheral blood mononuclear cells from type 2 diabetic patients. 2022 Jul 1
2 35620570 Empagliflozin-Metformin Combination Has Antioxidative and Anti-Inflammatory Properties that Correlate with Vascular Protection in Adults with Type 1 Diabetes. 2022 1
3 32674107 Combination of LMT-28 and Metformin Improves Beneficial Anti-Inflammatory Effect in Collagen-Induced Arthritis. 2021 3
4 33017649 Adipokines as a therapeutic target by metformin to improve metabolic function: A systematic review of randomized controlled trials. 2021 Jan 1
5 33580540 Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity. 2021 Jul 2
6 33798839 Effect of metformin on biomarkers of placental- mediated disease: A systematic review and meta-analysis. 2021 Apr 1
7 34115964 Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. 2021 Jul 13 1
8 34238029 Metformin Antagonizes Ovarian Cancer Cells Malignancy Through MSLN Mediated IL-6/STAT3 Signaling. 2021 Jan-Dec 3
9 34284806 Decreased SFRP5 correlated with excessive metabolic inflammation in polycystic ovary syndrome could be reversed by metformin: implication of its role in dysregulated metabolism. 2021 Jul 20 1
10 34572149 Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway. 2021 Sep 21 1
11 34607979 Knockdown of LKB1 Sensitizes Endometrial Cancer Cells via AMPK Activation. 2021 Nov 1 1
12 34881181 Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Catrcinoma by Inhibiting IL-6 Signaling Pathway. 2021 3
13 31840936 Insulin-Resistant Pathways Are Associated With Disease Activity in Rheumatoid Arthritis and Are Subject to Disease Modification Through Metabolic Reprogramming: A Potential Novel Therapeutic Approach. 2020 Jun 1
14 32258099 Metformin's Effects on Apoptosis of Esophageal Carcinoma Cells and Normal Esophageal Epithelial Cells: An In Vitro Comparative Study. 2020 1
15 32312819 Starvation and antimetabolic therapy promote cytokine release and recruitment of immune cells. 2020 May 5 1
16 32463794 Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19. 2020 May 27 2
17 32518807 Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion. 2020 Jun 12 2
18 32769032 Action of metformin therapy against advanced glycation, oxidative stress and inflammation in type 2 diabetes patients: 3 months follow-up study. 2020 Sep - Oct 1
19 32859615 Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial. 2020 Dec 1
20 32967076 Systemic Oxidative Stress and Visceral Adipose Tissue Mediators of NLRP3 Inflammasome and Autophagy Are Reduced in Obese Type 2 Diabetic Patients Treated with Metformin. 2020 Sep 21 1
21 33081905 [Metformin: one of the possible options to reduce the mortality of severe coronavirus disease 2019?] 2020 Sep 2
22 33116117 Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma. 2020 Oct 28 2
23 30318339 Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. 2019 Feb 5 2
24 30334082 Non-traditional biomarkers and incident diabetes in the Diabetes Prevention Program: comparative effects of lifestyle and metformin interventions. 2019 Jan 1
25 30334569 Metformin inhibits mTOR-HIF-1α axis and profibrogenic and inflammatory biomarkers in thioacetamide-induced hepatic tissue alterations. 2019 Jun 2
26 30520054 Metformin inhibits pro-inflammatory responses via targeting nuclear factor-κB in HaCaT cells. 2019 Jan 1
27 30628691 Protective effects of metformin on lipopolysaccharide‑induced airway epithelial cell injury via NF‑κB signaling inhibition. 2019 Mar 1
28 30959417 The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells. 2019 Jul 2
29 30988378 Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells. 2019 Nov 1
30 31154939 Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease. 2019 Aug 2 2
31 31337349 Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways. 2019 Jul 23 1
32 31346700 Metformin and ovarian cancer survival: is there a rational warrant for belief? 2019 Oct 1
33 31442575 Sitagliptin favorably modulates immune-relevant pathways in human beta cells. 2019 Oct 1
34 31683341 Treatment with Metformin and Combination of Metformin Plus Pioglitazone on Serum Levels of IL-6 and IL-8 in Polycystic Ovary Syndrome: A Randomized Clinical Trial. 2019 Nov 3
35 29148173 Metformin protects against intestinal barrier dysfunction via AMPKα1-dependent inhibition of JNK signalling activation. 2018 Jan 1
36 29540537 Metformin inhibits inflammatory signals in the gut by controlling AMPK and p38 MAP kinase activation. 2018 Jun 15 1
37 29545331 Metformin Suppresses Tumor Progression by Inactivating Stromal Fibroblasts in Ovarian Cancer. 2018 Jun 2
38 29589999 Biguanides Metformin and Phenformin Generate Therapeutic Effects via AMP-Activated Protein Kinase/Extracellular-Regulated Kinase Pathways in an In Vitro Model of Graves' Orbitopathy. 2018 Apr 1
39 30308035 Anti-metastatic effect of metformin via repression of interleukin 6-induced epithelial-mesenchymal transition in human colon cancer cells. 2018 3
40 28953677 Effects of metformin treatment on serum levels of C-reactive protein and interleukin-6 in women with polycystic ovary syndrome: a meta-analysis: A PRISMA-compliant article. 2017 Sep 4
41 26305116 Metformin inhibits proliferation and proinflammatory cytokines of human keratinocytes in vitro via mTOR-signaling pathway. 2016 Jul 1
42 26896068 Combination of metformin and 5-aminosalicylic acid cooperates to decrease proliferation and induce apoptosis in colorectal cancer cell lines. 2016 Feb 19 1
43 26963617 Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein. 2016 1
44 27418629 Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. 2016 Aug 19 1
45 27904436 Effects of metformin on blood and urine pro-inflammatory mediators in patients with type 2 diabetes. 2016 3
46 26081514 [Effects of metformin on the polarization and Notch 1 expression of RAW264.7 macrophages]. 2015 Apr 28 1
47 26120598 Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation. 2015 Feb 28 1
48 26141671 Metformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction. 2015 Nov 1
49 26320144 Effects of metformin on mitochondrial function of leukocytes from polycystic ovary syndrome patients with insulin resistance. 2015 Nov 1
50 24644001 Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal. 2014 May 15 7