Metformin

MYC proto-oncogene, bHLH transcription factor ; Homo sapiens







34 Article(s)
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1 34139918 Multidimensional mechanisms of metformin in cancer treatment. 2022 Apr 1
2 33650651 Metformin inhibits mTOR and c-Myc by decreasing YAP protein expression in OSCC cells. 2021 Mar 7
3 34164906 lncRNA MALAT1 participates in metformin inhibiting the proliferation of breast cancer cell. 2021 Aug 2
4 34436421 Metformin Decreases 2-HG Production through the MYC-PHGDH Pathway in Suppressing Breast Cancer Cell Proliferation. 2021 Jul 26 2
5 34887262 Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3. 2021 Dec 1
6 32208194 Metformin treatment decreases the expression of cancer stem cell marker CD44 and stemness related gene expression in primary oral cancer cells. 2020 May 2
7 32382652 If ineffective levels of transforming growth factors and their receptor account for old age being a risk factor for Alzheimer's disease, then increasing TGFBR2 might be therapeutic. 2020 1
8 32641388 Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4+ T Cell Effector Functions and Activation-Induced Metabolic Reprogramming. 2020 Aug 15 2
9 32728616 Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells. 2020 Sep 25 1
10 33081077 Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells. 2020 Oct 16 2
11 30693913 Metformin Inhibit Lung Cancer Cell Growth and Invasion in Vitro as Well as Tumor Formation in Vivo Partially by Activating PP2A. 2019 Jan 29 2
12 29319171 The key genes underlying pathophysiology association between the type 2-diabetic and colorectal cancer. 2018 Nov 1
13 29323154 Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism. 2018 Jan 11 1
14 29383869 Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults. 2018 Apr 1
15 30221473 Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling. 2018 Nov 4
16 28819383 Metformin Inhibits Tumorigenesis and Tumor Growth of Breast Cancer Cells by Upregulating miR-200c but Downregulating AKT2 Expression. 2017 1
17 29085506 Role of metformin in inhibiting estrogen-induced proliferation and regulating ERα and ERβ expression in human endometrial cancer cells. 2017 Oct 1
18 29088816 Metformin inhibits esophageal squamous cell carcinoma-induced angiogenesis by suppressing JAK/STAT3 signaling pathway. 2017 Sep 26 1
19 26956973 Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells. 2016 Feb 4
20 26986571 Anticancer effect of metformin on estrogen receptor-positive and tamoxifen-resistant breast cancer cell lines. 2016 May 1
21 27760406 Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine. 2016 Nov 1
22 25854169 Metformin inhibits thyroid cancer cell growth, migration, and EMT through the mTOR pathway. 2015 Aug 2
23 26083494 Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action. 2015 Jun 1
24 26172303 Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer. 2015 Sep 15 3
25 26236947 AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation. 2015 Oct 1
26 26365176 MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells. 2015 Oct 6 1
27 26885449 Metformin inhibits salivary adenocarcinoma growth through cell cycle arrest and apoptosis. 2015 3
28 24285728 Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. 2014 Feb 1 1
29 24980829 Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cells. 2014 Jun 30 1
30 25056111 Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation. 2014 Jul 24 1
31 25608995 [Effects of metformin on the estrogen-induced proliferation and the expression of ER in human endometrial cancer cells]. 2014 Dec 2
32 22575507 Metformin induces differentiation in acute promyelocytic leukemia by activating the MEK/ERK signaling pathway. 2012 Jun 8 1
33 22643892 Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC. 2012 May 29 5
34 23041548 Carbon source and myc expression influence the antiproliferative actions of metformin. 2012 Dec 1 2