Protein Name nuclear factor kappa B subunit 1
Organism Homo sapiens
Gene ID 4790
Gene Symbol


UniProt P19838 (NFKB1_HUMAN)
Relationships Total Number of functionally related compound(s) : 4834
Total Number of Articles : 12373

nuclear factor kappa B subunit 1

Gene Summary

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020]

  • nuclear factor NF-kappa-B p105 subunit
  • DNA-binding factor KBF1
  • nuclear factor NF-kappa-B p50 subunit
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