Protein Name erb-b2 receptor tyrosine kinase 2
Organism Homo sapiens
Gene ID 2064
Gene Symbol


Relationships Total Number of functionally related compound(s) : 2723
Total Number of Articles : 8257

erb-b2 receptor tyrosine kinase 2

Gene Summary

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

  • receptor tyrosine-protein kinase erbB-2
  • c-erb B2/neu protein
  • herstatin
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