CPRiL

MTOR

mechanistic target of rapamycin kinase

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]

• serine/threonine-protein kinase mTOR
• FK506 binding protein 12-rapamycin associated protein 2
• FK506-binding protein 12-rapamycin complex-associated protein 1
FKBP-rapamycin associated protein
FKBP12-rapamycin complex-associated protein 1
mammalian target of rapamycin
mechanistic target of rapamycin (serine/threonine kinase)
rapamycin and FKBP12 target 1
rapamycin associated protein FRAP2
rapamycin target protein 1
FRAP
FRAP1
FRAP2
RAFT1
RAPT1
SKS