Metformin

signal transducer and activator of transcription 3 ; Homo sapiens







49 Article(s)
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1 35072253 Metformin in selected malignancies in women. 2022 Jan 24 1
2 35550195 Metformin-induced downregulation of c-Met is a determinant of sensitivity in MDA-MB-468 breast cancer cells. 2022 Jul 12 1
3 32674107 Combination of LMT-28 and Metformin Improves Beneficial Anti-Inflammatory Effect in Collagen-Induced Arthritis. 2021 1
4 32791889 Metformin Reduces Thyroid Cancer Tumor Growth in the Metastatic Niche of Bone by Inhibiting Osteoblastic RANKL Productions. 2021 May 1
5 33262823 Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1α/PKM2/STAT3 pathway. 2021 Jan 2
6 33603170 Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. 2021 Mar 1
7 34154617 Correction to: Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts. 2021 Jun 21 1
8 34238029 Metformin Antagonizes Ovarian Cancer Cells Malignancy Through MSLN Mediated IL-6/STAT3 Signaling. 2021 Jan-Dec 3
9 34302119 Correction: Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling. 2021 Aug 1
10 34881181 Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Catrcinoma by Inhibiting IL-6 Signaling Pathway. 2021 2
11 34887262 Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3. 2021 Dec 1
12 32258099 Metformin's Effects on Apoptosis of Esophageal Carcinoma Cells and Normal Esophageal Epithelial Cells: An In Vitro Comparative Study. 2020 2
13 32460059 Metformin suppresses the growth of leukemia cells partly through downregulation of AXL receptor tyrosine kinase. 2020 Jul 1
14 32470453 The impact of metformin and aspirin on T-cell mediated inflammation: A systematic review of in vitro and in vivo findings. 2020 Aug 15 1
15 33116117 Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma. 2020 Oct 28 2
16 33126079 Activation of AMPK suppresses S1P-induced airway smooth muscle cells proliferation and its potential mechanisms. 2020 Dec 1
17 33149616 Metformin Combined with 4SC-202 Inhibited the Migration and Invasion of OSCC via STAT3/TWIST1. 2020 3
18 30019648 Metformin one in a Million Efficient Medicines for Rheumatoid Arthritis Complications: Inflammation, Osteoblastogenesis, Cardiovascular Disease, Malignancies. 2019 1
19 31154939 Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease. 2019 Aug 2 1
20 31278880 Effects of metformin and phenformin on apoptosis and epithelial-mesenchymal transition in chemoresistant rectal cancer. 2019 Sep 1
21 31337349 Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways. 2019 Jul 23 2
22 29472557 Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms. 2018 Feb 22 1
23 28011481 Metformin Exerts Antiproliferative and Anti-metastatic Effects Against Cholangiocarcinoma Cells by Targeting STAT3 and NF-ĸB. 2017 Jan 1
24 28030813 Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation. 2017 Jan 31 7
25 28043910 Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis. 2017 Mar 28 3
26 28114390 High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer. 2017 5
27 28345832 Metformin Inhibits Migration and Invasion of Cholangiocarcinoma Cells 2017 Feb 1 2
28 28445726 Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation. 2017 Apr 25 1
29 28823275 [Effect of Metformin on Proliferation of Multiple Myeloma Cells]. 2017 Aug 1
30 28837141 Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-β1/STAT3 axis-regulated EMT. 2017 Aug 24 5
31 28964970 Metformin triggers apoptosis in PEL cells and alters bortezomib-induced Unfolded Protein Response increasing its cytotoxicity and inhibiting KSHV lytic cycle activation. 2017 Dec 1
32 29073599 Combination of Solamargine and Metformin Strengthens IGFBP1 Gene Expression Through Inactivation of Stat3 and Reciprocal Interaction Between FOXO3a and SP1. 2017 1
33 29088816 Metformin inhibits esophageal squamous cell carcinoma-induced angiogenesis by suppressing JAK/STAT3 signaling pathway. 2017 Sep 26 2
34 27126953 Metformin attenuates graft-versus-host disease via restricting mammalian target of rapamycin/signal transducer and activator of transcription 3 and promoting adenosine monophosphate-activated protein kinase-autophagy for the balance between T helper 17 and Tregs. 2016 Jul 3
35 27919027 Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. 2016 Nov 8 1
36 25370454 Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma. 2015 Jun 1 1
37 25462562 Metformin enhances the anti-adipogenic effects of atorvastatin via modulation of STAT3 and TGF-β/Smad3 signaling. 2015 Jan 2 1
38 26056043 Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. 2015 Aug 28 1
39 26360050 Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance. 2015 3
40 26641266 Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages. 2015 1
41 24302004 Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids. 2014 Jan 15 2
42 24322659 Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models. 2014 Feb 1
43 24577086 Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. 2014 Feb 27 7
44 23277563 Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. 2013 Jan 15 1
45 23526220 Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway. 2013 Aug 5
46 22189713 Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. 2012 Jan 15 10
47 23162655 Metformin inhibits leptin-induced growth and migration of glioblastoma cells. 2012 Nov 2
48 21776823 Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling. 2011 2
49 15236798 AMPK activation may suppress hepatic production of C-reactive protein by stimulating nitric oxide synthase. 2004 1