Protein Name mitogen-activated protein kinase 1
Organism Homo sapiens
Gene ID 5594
Gene Symbol


UniProt P28482 (MK01_HUMAN), Q1HBJ4 (Q1HBJ4_HUMAN), Q499G7 (Q499G7_HUMAN)
Relationships Total Number of functionally related compound(s) : 4181
Total Number of Articles : 11634

mitogen-activated protein kinase 1

Gene Summary

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

  • mitogen-activated protein kinase 1
  • MAP kinase 1
  • MAP kinase 2
Click to show/hide the synonyms