Protein Name mechanistic target of rapamycin kinase
Organism Mus musculus
Gene ID 56717
Gene Symbol


Relationships Total Number of functionally related compound(s) : 1120
Total Number of Articles : 2257

mechanistic target of rapamycin kinase

Gene Summary

Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and neuronal action potential. Acts upstream of or within several processes, including heart development; positive regulation of cellular component biogenesis; and regulation of protein phosphorylation. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex. Colocalizes with PML body. Is expressed in central nervous system; early conceptus; oocyte; respiratory system; and retina. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Apr 2022]

  • serine/threonine-protein kinase mTOR
  • FK506 binding protein 12-rapamycin associated protein 1
  • FK506-binding protein 12-rapamycin complex-associated protein 1
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