CPRiL

Protein Name	mechanistic target of rapamycin kinase
Organism	Mus musculus
Gene ID	56717
Gene Symbol	Mtor
UniProt	Q9JLN9 (MTOR_MOUSE)
Relationships	Total Number of functionally related compound(s) : 1120 Total Number of Articles : 2257
Description	mechanistic target of rapamycin kinase
Gene Summary	Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and neuronal action potential. Acts upstream of or within several processes, including heart development; positive regulation of cellular component biogenesis; and regulation of protein phosphorylation. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex. Colocalizes with PML body. Is expressed in central nervous system; early conceptus; oocyte; respiratory system; and retina. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Apr 2022]
synonyms	serine/threonine-protein kinase mTOR FK506 binding protein 12-rapamycin associated protein 1 FK506-binding protein 12-rapamycin complex-associated protein 1 FKBP-rapamycin associated protein (FRAP) FKBP12-rapamycin complex-associated protein angiopoietin-like factor CDT6 mammalian target of rapamycin mechanistic target of rapamycin (serine/threonine kinase) rapamycin target protein 1 2610315D21Rik FRAP FRAP2 Frap1 RAFT1 RAPT1 flat Click to show/hide the synonyms
Properties