| 1 |
34806449 | Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model. | 2022 Jan 1 |
1 |
| 2 |
32994182 | Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling. | 2021 Jan |
1 |
| 3 |
33543290 | Metformin: a novel promising option for fertility preservation during cyclophosphamide-based chemotherapy. | 2021 Jan 22 |
4 |
| 4 |
33575476 | Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways. | 2021 Mar 26 |
1 |
| 5 |
33609419 | Impact of diabetes on promoting the growth of breast cancer. | 2021 May |
1 |
| 6 |
33947424 | Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts. | 2021 May 4 |
5 |
| 7 |
34688695 | Blunting p38 MAPKα and ERK1/2 activities by empagliflozin enhances the antifibrotic effect of metformin and augments its AMPK-induced NF-κB inactivation in mice intoxicated with carbon tetrachloride. | 2021 Dec 1 |
1 |
| 8 |
30820523 | Differential Effects of Rapamycin and Metformin in Combination With Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes. | 2020 Jan 1 |
1 |
| 9 |
31818851 | A Phase IIa Trial of Metformin for Colorectal Cancer Risk Reduction among Individuals with History of Colorectal Adenomas and Elevated Body Mass Index. | 2020 Feb |
4 |
| 10 |
31874168 | Hyperactive Akt-mTOR pathway as a therapeutic target for pain hypersensitivity in Cntnap2-deficient mice. | 2020 Mar 15 |
1 |
| 11 |
31904843 | Metformin enhances the immunomodulatory potential of adipose-derived mesenchymal stem cells through STAT1 in an animal model of lupus. | 2020 Jun 1 |
2 |
| 12 |
31945013 | Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR. | 2020 Jan 16 |
2 |
| 13 |
32843973 | Diabetes mellitus type 2 drives metabolic reprogramming to promote pancreatic cancer growth. | 2020 Aug |
1 |
| 14 |
32908958 | The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth. | 2020 Sep |
1 |
| 15 |
33099954 | Metformin induces apoptosis of melanoma B16 cells via PI3K/Akt/mTOR signaling pathways. | 2020 Jul-Aug |
2 |
| 16 |
30779140 | Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7(Nek7) expression. | 2019 Feb 19 |
1 |
| 17 |
30909226 | Metformin Therapy Aggravates Neurodegenerative Processes in ApoE-/- Mice. | 2019 |
3 |
| 18 |
30945296 | Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression. | 2019 Sep |
1 |
| 19 |
30972229 | Effect of a High-Fat Diet and Metformin on Placental mTOR Signaling in Mice. | 2019 Apr |
5 |
| 20 |
31182921 | Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy. | 2019 |
4 |
| 21 |
31273547 | Basic Research in Diabetic Nephropathy Health Care: A study of the Renoprotective Mechanism of Metformin. | 2019 Jul 4 |
2 |
| 22 |
31467666 | Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE-/- mice. | 2019 |
3 |
| 23 |
31698699 | Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy. | 2019 Nov 6 |
1 |
| 24 |
29253574 | Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice. | 2018 Mar |
2 |
| 25 |
29554968 | Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways. | 2018 Mar 20 |
1 |
| 26 |
29859833 | Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR. | 2018 Aug 1 |
3 |
| 27 |
30025915 | Metformin suppresses growth and adrenocorticotrophic hormone secretion in mouse pituitary corticotroph tumor AtT20 cells. | 2018 Dec 15 |
2 |
| 28 |
30275441 | Metformin Increases Cardiac Rupture After Myocardial Infarction via the AMPK-MTOR/PGC-1α Signaling Pathway in Rats with Acute Myocardial Infarction. | 2018 Oct 2 |
2 |
| 29 |
30409193 | Metformin induces apoptosis in mesenchymal stromal cells and dampens their therapeutic efficacy in infarcted myocardium. | 2018 Nov 8 |
1 |
| 30 |
27803295 | Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis. | 2017 Jan 1 |
1 |
| 31 |
28242651 | Metformin Suppresses Systemic Autoimmunity in Roquinsan/san Mice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3. | 2017 Apr 1 |
4 |
| 32 |
28274614 | Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. | 2017 May 15 |
2 |
| 33 |
26921394 | High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum. | 2016 Mar |
1 |
| 34 |
26943960 | Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice. | 2016 Mar 15 |
1 |
| 35 |
27223262 | Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer. | 2016 Jun 21 |
1 |
| 36 |
25456211 | AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell. | 2015 |
1 |
| 37 |
25576058 | Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms. | 2015 May |
1 |
| 38 |
25879666 | Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. | 2015 |
1 |
| 39 |
25909163 | Metformin potentiates rapamycin and cisplatin in gastric cancer in mice. | 2015 May 20 |
1 |
| 40 |
23949159 | Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice. | 2014 Feb |
3 |
| 41 |
24905037 | Therapeutic potential of metformin in papillary thyroid cancer in vitro and in vivo. | 2014 Aug 5 |
1 |
| 42 |
24466367 | Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling. | 2013 Dec 1 |
1 |
| 43 |
22378068 | Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. | 2012 Mar 1 |
1 |
| 44 |
21465524 | Metformin sensitizes insulin signaling through AMPK-mediated PTEN down-regulation in preadipocyte 3T3-L1 cells. | 2011 May |
2 |
| 45 |
21543517 | Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth. | 2011 Jun 15 |
2 |
| 46 |
20363874 | AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation. | 2010 Jun |
1 |
| 47 |
20564343 | Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. | 2010 Jul |
2 |
| 48 |
20810672 | Metformin prevents tobacco carcinogen--induced lung tumorigenesis. | 2010 Sep |
7 |
| 49 |
19501448 | Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia. | 2009 Aug |
1 |