Metformin

mechanistic target of rapamycin kinase ; Mus musculus







49 Article(s)
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1 34806449 Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model. 2022 Jan 1 1
2 32994182 Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling. 2021 Jan 1
3 33543290 Metformin: a novel promising option for fertility preservation during cyclophosphamide-based chemotherapy. 2021 Jan 22 4
4 33575476 Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways. 2021 Mar 26 1
5 33609419 Impact of diabetes on promoting the growth of breast cancer. 2021 May 1
6 33947424 Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts. 2021 May 4 5
7 34688695 Blunting p38 MAPKα and ERK1/2 activities by empagliflozin enhances the antifibrotic effect of metformin and augments its AMPK-induced NF-κB inactivation in mice intoxicated with carbon tetrachloride. 2021 Dec 1 1
8 30820523 Differential Effects of Rapamycin and Metformin in Combination With Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes. 2020 Jan 1 1
9 31818851 A Phase IIa Trial of Metformin for Colorectal Cancer Risk Reduction among Individuals with History of Colorectal Adenomas and Elevated Body Mass Index. 2020 Feb 4
10 31874168 Hyperactive Akt-mTOR pathway as a therapeutic target for pain hypersensitivity in Cntnap2-deficient mice. 2020 Mar 15 1
11 31904843 Metformin enhances the immunomodulatory potential of adipose-derived mesenchymal stem cells through STAT1 in an animal model of lupus. 2020 Jun 1 2
12 31945013 Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR. 2020 Jan 16 2
13 32843973 Diabetes mellitus type 2 drives metabolic reprogramming to promote pancreatic cancer growth. 2020 Aug 1
14 32908958 The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth. 2020 Sep 1
15 33099954 Metformin induces apoptosis of melanoma B16 cells via PI3K/Akt/mTOR signaling pathways. 2020 Jul-Aug 2
16 30779140 Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7(Nek7) expression. 2019 Feb 19 1
17 30909226 Metformin Therapy Aggravates Neurodegenerative Processes in ApoE-/- Mice. 2019 3
18 30945296 Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression. 2019 Sep 1
19 30972229 Effect of a High-Fat Diet and Metformin on Placental mTOR Signaling in Mice. 2019 Apr 5
20 31182921 Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy. 2019 4
21 31273547 Basic Research in Diabetic Nephropathy Health Care: A study of the Renoprotective Mechanism of Metformin. 2019 Jul 4 2
22 31467666 Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE-/- mice. 2019 3
23 31698699 Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy. 2019 Nov 6 1
24 29253574 Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice. 2018 Mar 2
25 29554968 Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways. 2018 Mar 20 1
26 29859833 Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR. 2018 Aug 1 3
27 30025915 Metformin suppresses growth and adrenocorticotrophic hormone secretion in mouse pituitary corticotroph tumor AtT20 cells. 2018 Dec 15 2
28 30275441 Metformin Increases Cardiac Rupture After Myocardial Infarction via the AMPK-MTOR/PGC-1α Signaling Pathway in Rats with Acute Myocardial Infarction. 2018 Oct 2 2
29 30409193 Metformin induces apoptosis in mesenchymal stromal cells and dampens their therapeutic efficacy in infarcted myocardium. 2018 Nov 8 1
30 27803295 Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis. 2017 Jan 1 1
31 28242651 Metformin Suppresses Systemic Autoimmunity in Roquinsan/san Mice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3. 2017 Apr 1 4
32 28274614 Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. 2017 May 15 2
33 26921394 High Sensitivity of an Ha-RAS Transgenic Model of Superficial Bladder Cancer to Metformin Is Associated with ∼240-Fold Higher Drug Concentration in Urine than Serum. 2016 Mar 1
34 26943960 Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice. 2016 Mar 15 1
35 27223262 Enhanced anti-tumor activity and cytotoxic effect on cancer stem cell population of metformin-butyrate compared with metformin HCl in breast cancer. 2016 Jun 21 1
36 25456211 AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell. 2015 1
37 25576058 Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms. 2015 May 1
38 25879666 Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. 2015 1
39 25909163 Metformin potentiates rapamycin and cisplatin in gastric cancer in mice. 2015 May 20 1
40 23949159 Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice. 2014 Feb 3
41 24905037 Therapeutic potential of metformin in papillary thyroid cancer in vitro and in vivo. 2014 Aug 5 1
42 24466367 Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling. 2013 Dec 1 1
43 22378068 Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. 2012 Mar 1 1
44 21465524 Metformin sensitizes insulin signaling through AMPK-mediated PTEN down-regulation in preadipocyte 3T3-L1 cells. 2011 May 2
45 21543517 Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth. 2011 Jun 15 2
46 20363874 AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation. 2010 Jun 1
47 20564343 Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. 2010 Jul 2
48 20810672 Metformin prevents tobacco carcinogen--induced lung tumorigenesis. 2010 Sep 7
49 19501448 Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia. 2009 Aug 1