Protein Name | protein kinase AMP-activated catalytic subunit alpha 2 |
---|---|
Organism | Homo sapiens |
Gene ID | 5563 |
Gene Symbol | PRKAA2 |
UniProt | P54646 (AAPK2_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
919
Total Number of Articles : 1765 |
Description |
protein kinase AMP-activated catalytic subunit alpha 2 |
Gene Summary |
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008] |
synonyms |
|
Properties | |