Protein Name tumor necrosis factor
Organism Mus musculus
Gene ID 21926
Gene Symbol


UniProt P06804 (TNFA_MOUSE), Q3U593 (Q3U593_MOUSE), A0A0R4J210 (A0A0R4J210_MOUSE)
Relationships Total Number of functionally related compound(s) : 5931
Total Number of Articles : 13761

tumor necrosis factor

Gene Summary

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

  • tumor necrosis factor
  • cachectin
  • tumor necrosis factor ligand 1f
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