Protein Name serpin family E member 1
Organism Homo sapiens
Gene ID 5054
Gene Symbol


UniProt P05121 (PAI1_HUMAN), A0A024QYT5 (A0A024QYT5_HUMAN)
Relationships Total Number of functionally related compound(s) : 1182
Total Number of Articles : 2204

serpin family E member 1

Gene Summary

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. The protein also functions as a component of innate antiviral immunity. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. [provided by RefSeq, Aug 2020]

  • plasminogen activator inhibitor 1
  • endothelial plasminogen activator inhibitor
  • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
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