Protein Name protein kinase AMP-activated catalytic subunit alpha 1
Organism Homo sapiens
Gene ID 5562
Gene Symbol


UniProt Q13131 (AAPK1_HUMAN)
Relationships Total Number of functionally related compound(s) : 812
Total Number of Articles : 1480

protein kinase AMP-activated catalytic subunit alpha 1

Gene Summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

  • 5'-AMP-activated protein kinase catalytic subunit alpha-1
  • 5'-AMP-activated protein kinase, catalytic alpha-1 chain
  • ACACA kinase
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