CPRiL

Protein Name	protein kinase AMP-activated catalytic subunit alpha 1
Organism	Homo sapiens
Gene ID	5562
Gene Symbol	PRKAA1
UniProt	Q13131 (AAPK1_HUMAN)
Relationships	Total Number of functionally related compound(s) : 812 Total Number of Articles : 1480
Description	protein kinase AMP-activated catalytic subunit alpha 1
Gene Summary	The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
synonyms	5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase, catalytic alpha-1 chain ACACA kinase AMP -activate kinase alpha 1 subunit AMP-activated protein kinase, catalytic, alpha-1 AMPK subunit alpha-1 AMPK, alpha, 1 HMGCR kinase acetyl-CoA carboxylase kinase hydroxymethylglutaryl-CoA reductase kinase protein kinase, AMP-activated, alpha 1 catalytic subunit tau-protein kinase PRKAA1 AMPK AMPK alpha 1 AMPKa1 Click to show/hide the synonyms
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