| 1 |
35147740 | Prediction of drug-drug interaction potential mediated by transporters between dasatinib and metformin, pravastatin, and rosuvastatin using physiologically based pharmacokinetic modeling. | 2022 Mar |
2 |
| 2 |
35163393 | Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells. | 2022 Jan 27 |
2 |
| 3 |
35183887 | Tamsulosin alters the pharmacokinetics of metformin via inhibition of renal multidrug and toxin extrusion protein 1 and organic cation transporter 2 in rats. | 2022 Apr 1 |
1 |
| 4 |
32989831 | Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects. | 2021 Apr |
1 |
| 5 |
34064886 | A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators. | 2021 May 11 |
2 |
| 6 |
34502566 | Properties of Transport Mediated by the Human Organic Cation Transporter 2 Studied in a Polarized Three-Dimensional Epithelial Cell Culture Model. | 2021 Sep 6 |
1 |
| 7 |
34884730 | Substrate-Dependent Trans-Stimulation of Organic Cation Transporter 2 Activity. | 2021 Nov 29 |
1 |
| 8 |
31936070 | Extended Intake of Mulberry Leaf Extract Delayed Metformin Elimination via Inhibiting the Organic Cation Transporter 2. | 2020 Jan 7 |
1 |
| 9 |
32449077 | A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug-Drug-Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals. | 2020 Nov |
4 |
| 10 |
32455555 | Pharmacokinetic Interaction between Metformin and Verapamil in Rats: Inhibition of the OCT2-Mediated Renal Excretion of Metformin by Verapamil. | 2020 May 21 |
3 |
| 11 |
32472157 | A drug-drug interaction study to evaluate the impact of peficitinib on OCT1- and MATE1-mediated transport of metformin in healthy volunteers. | 2020 Aug |
1 |
| 12 |
30804576 | Effects of SLC22A2 (rs201919874) and SLC47A2 (rs138244461) genetic variants on Metformin Pharmacokinetics in Pakistani T2DM patients. | 2019 Feb |
1 |
| 13 |
30934600 | Metformin Pharmacogenetics: Effects of SLC22A1, SLC22A2, and SLC22A3 Polymorphisms on Glycemic Control and HbA1c Levels. | 2019 Mar 25 |
2 |
| 14 |
30959948 | Association between Polymorphisms of OCT1 and Metabolic Response to Metformin in Women with Polycystic Ovary Syndrome. | 2019 Apr 7 |
1 |
| 15 |
31012983 | Altered Glycemic Control Associated With Polymorphisms in the SLC22A1 (OCT1) Gene in a Mexican Population With Type 2 Diabetes Mellitus Treated With Metformin: A Cohort Study. | 2019 Oct |
3 |
| 16 |
29204687 | A physiologically based pharmacokinetic (PBPK) parent-metabolite model of the chemotherapeutic zoptarelin doxorubicin-integration of in vitro results, Phase I and Phase II data and model application for drug-drug interaction potential analysis. | 2018 Feb |
1 |
| 17 |
29490902 | Prediction of the Effects of Renal Impairment on Clearance for Organic Cation Drugs that Undergo Renal Secretion: A Simulation-Based Study. | 2018 May |
2 |
| 18 |
29914345 | Implication of critical pharmacokinetic gene variants on therapeutic response to metformin in Type 2 diabetes. | 2018 Jul 1 |
2 |
| 19 |
30733798 | Interaction of rs316019 variants of SLC22A2 with metformin and other drugs- an in silico analysis. | 2018 Dec |
3 |
| 20 |
28069720 | Pregnancy Increases the Renal Secretion of N1-methylnicotinamide, an Endogenous Probe for Renal Cation Transporters, in Patients Prescribed Metformin. | 2017 Mar |
1 |
| 21 |
28253084 | Organic Cation Transporter 2 (OCT2/SLC22A2) Gene Variation in the South African Bantu-Speaking Population and Functional Promoter Variants. | 2017 Mar |
1 |
| 22 |
28483424 | The Effect of Uremic Solutes on the Organic Cation Transporter 2. | 2017 Sep |
1 |
| 23 |
26784938 | The MATE1 rs2289669 polymorphism affects the renal clearance of metformin following ranitidine treatment. | 2016 Apr |
4 |
| 24 |
26974526 | The Effect of Dolutegravir on the Pharmacokinetics of Metformin in Healthy Subjects. | 2016 Aug 1 |
2 |
| 25 |
27555891 | Pharmacogenetic studies update in type 2 diabetes mellitus. | 2016 Aug 10 |
1 |
| 26 |
27609360 | Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients. | 2016 Dec |
2 |
| 27 |
27828777 | SLC22A2 - mapping genomic variations within South African indigenous and admixed populations. | 2016 Dec 1 |
2 |
| 28 |
25359200 | Organic cation transporter-mediated drug-drug interaction potential between berberine and metformin. | 2015 |
1 |
| 29 |
25527093 | Development of a living membrane comprising a functional human renal proximal tubule cell monolayer on polyethersulfone polymeric membrane. | 2015 Mar |
2 |
| 30 |
25573751 | Polymorphism of organic cation transporter 2 improves glucose-lowering effect of metformin via influencing its pharmacokinetics in Chinese type 2 diabetic patients. | 2015 Feb |
3 |
| 31 |
25662675 | The variant organic cation transporter 2 (OCT2)-T201M contribute to changes in insulin resistance in patients with type 2 diabetes treated with metformin. | 2015 Apr |
6 |
| 32 |
24657329 | Involvement of organic cation transporter 2 inhibition in potential mechanisms of antidepressant action. | 2014 Aug 4 |
1 |
| 33 |
25125398 | Development of an LC-MS/MS method for high throughput quantification of metformin uptake in transporter inhibition assays. | 2014 Sep 15 |
2 |
| 34 |
25394090 | The effect of dolutegravir on the pharmacokinetics of metformin in healthy subjects. | 2014 |
2 |
| 35 |
22861817 | Differential expression of organic cation transporter OCT-3 in oral premalignant and malignant lesions: potential implications in the antineoplastic effects of metformin. | 2013 Mar |
1 |
| 36 |
23305245 | Trimethoprim-metformin interaction and its genetic modulation by OCT2 and MATE1 transporters. | 2013 Nov |
1 |
| 37 |
23582785 | Transport of biguanides by human organic cation transporter OCT2. | 2013 Jun |
3 |
| 38 |
23709117 | Substrate-dependent ligand inhibition of the human organic cation transporter OCT2. | 2013 Aug |
1 |
| 39 |
23852330 | Polyspecific organic cation transporters and their biomedical relevance in kidney. | 2013 Sep |
1 |
| 40 |
24001450 | Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs). | 2013 Nov 15 |
1 |
| 41 |
24026623 | Assessment of vandetanib as an inhibitor of various human renal transporters: inhibition of multidrug and toxin extrusion as a possible mechanism leading to decreased cisplatin and creatinine clearance. | 2013 Dec |
1 |
| 42 |
22590580 | Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition. | 2012 |
4 |
| 43 |
22735389 | Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients. | 2012 Sep |
3 |
| 44 |
21677353 | [Metformin - mechanisms of action and use for the treatment of type 2 diabetes mellitus]. | 2011 May 6 |
3 |
| 45 |
21779389 | Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs). | 2011 |
2 |
| 46 |
20139901 | SLC22A2 gene 808 G/T variant is related to plasma lactate concentration in Chinese type 2 diabetics treated with metformin. | 2010 Feb |
3 |
| 47 |
19251820 | Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser. | 2009 Jun |
2 |
| 48 |
19483665 | Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. | 2009 Jul |
7 |
| 49 |
18303133 | Memantine-induced myoclonus and delirium exacerbated by trimethoprim. | 2008 Mar |
1 |
| 50 |
18401339 | Genetic variants of the organic cation transporter 2 influence the disposition of metformin. | 2008 Nov |
4 |