| 1 |
35427214 | Metformin induces myeloma cells necrosis and apoptosis and it is considered for therapeutic use. | 2022 Apr 15 |
1 |
| 2 |
35497918 | Correlation of Serum IGF-1R, VEGF, and ET Levels with Bone Mineral Density in Type 2 Diabetic Mellitus Patients Treated with Metformin Plus α-Glucosidase Inhibitors. | 2022 |
1 |
| 3 |
33007330 | FGFR1 overexpression renders breast cancer cells resistant to metformin through activation of IRS1/ERK signaling. | 2021 Jan |
2 |
| 4 |
32982447 | Preventative and Therapeutic Effects of Metformin in Gastric Cancer: A New Contribution of an Old Friend. | 2020 |
1 |
| 5 |
31028998 | Metformin inhibits the proliferation of rheumatoid arthritis fibroblast-like synoviocytes through IGF-IR/PI3K/AKT/m-TOR pathway. | 2019 Jul |
4 |
| 6 |
31205529 | Metformin Induces Apoptosis and Inhibits Proliferation through the AMP-Activated Protein Kinase and Insulin-like Growth Factor 1 Receptor Pathways in the Bile Duct Cancer Cells. | 2019 |
7 |
| 7 |
30025915 | Metformin suppresses growth and adrenocorticotrophic hormone secretion in mouse pituitary corticotroph tumor AtT20 cells. | 2018 Dec 15 |
2 |
| 8 |
30154647 | Combined treatment with metformin and gefitinib overcomes primary resistance to EGFR-TKIs with EGFR mutation via targeting IGF-1R signaling pathway. | 2018 |
1 |
| 9 |
27857021 | Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo. | 2017 Jul |
1 |
| 10 |
28253329 | Metformin inhibits the proliferation of benign prostatic epithelial cells. | 2017 |
3 |
| 11 |
28947975 | Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway. | 2017 Sep 1 |
2 |
| 12 |
29241458 | Inhibition of the IGF signaling pathway reverses cisplatin resistance in ovarian cancer cells. | 2017 Dec 14 |
4 |
| 13 |
26706833 | The influence of insulin-like Growth Factor-1-Receptor expression and endocrine treatment on clinical outcome of postmenopausal hormone receptor positive breast cancer patients: A Dutch TEAM substudy analysis. | 2016 Apr |
1 |
| 14 |
26708419 | The anti-diabetic drug metformin inhibits pancreatic cancer cell proliferation in vitro and in vivo: Study of the microRNAs associated with the antitumor effect of metformin. | 2016 Mar |
2 |
| 15 |
27144340 | Metformin restores crizotinib sensitivity in crizotinib-resistant human lung cancer cells through inhibition of IGF1-R signaling pathway. | 2016 Jun 7 |
2 |
| 16 |
27391065 | Metformin as a new anti-cancer drug in adrenocortical carcinoma. | 2016 Aug 2 |
1 |
| 17 |
27488947 | Metformin Enhances the Therapy Effects of Anti-IGF-1R mAb Figitumumab to NSCLC. | 2016 Aug 4 |
4 |
| 18 |
25305450 | Metformin displays anti-myeloma activity and synergistic effect with dexamethasone in in vitro and in vivo xenograft models. | 2015 Jan 28 |
3 |
| 19 |
25640355 | Metformin down-regulates endometrial carcinoma cell secretion of IGF-1 and expression of IGF-1R. | 2015 |
3 |
| 20 |
25687657 | Modulation of the IGF system and proliferation in human endometrial stromal cells by metformin: a dose-dependent effect. | 2015 Aug |
1 |
| 21 |
25862373 | Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor. | 2015 May 22 |
4 |
| 22 |
26201966 | Metformin effects on biochemical recurrence and metabolic signaling in the prostate. | 2015 Nov |
2 |
| 23 |
26287334 | Combinational Therapy Enhances the Effects of Anti-IGF-1R mAb Figitumumab to Target Small Cell Lung Cancer. | 2015 |
1 |
| 24 |
24437490 | Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling. | 2014 Apr |
6 |
| 25 |
24603137 | Human granulosa cells: insulin and insulin-like growth factor-1 receptors and aromatase expression modulation by metformin. | 2014 |
4 |
| 26 |
24627035 | Are growth factor receptors modulated by metformin in human endometrial stromal cells after stimulation with androgen and insulin? | 2014 Aug |
2 |
| 27 |
25143389 | Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors. | 2014 Oct 3 |
3 |
| 28 |
25289085 | Regulation of insulin-like growth factor signaling by metformin in endometrial cancer cells. | 2014 Nov |
4 |
| 29 |
23620761 | Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners. | 2013 |
2 |
| 30 |
23663483 | Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells. | 2013 May 10 |
2 |
| 31 |
24107633 | Glucose promotes breast cancer aggression and reduces metformin efficacy. | 2013 Dec 15 |
2 |
| 32 |
22038047 | Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells. | 2012 Feb |
1 |
| 33 |
23141431 | Metformin enhances the action of insulin on porcine granulosa-lutein cells in vitro. | 2012 Dec |
1 |
| 34 |
21597332 | The insulin receptor substrate (IRS) proteins: at the intersection of metabolism and cancer. | 2011 Jun 1 |
1 |
| 35 |
21862872 | Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions. | 2011 Sep 1 |
2 |
| 36 |
19858375 | If mammalian target of metformin indirectly is mammalian target of rapamycin, then the insulin-like growth factor-1 receptor axis will audit the efficacy of metformin in cancer clinical trials. | 2009 Nov 20 |
2 |