| 1 |
34427916 | Metformin accelerates wound healing by Akt phosphorylation of gingival fibroblasts in insulin-resistant prediabetes mice. | 2022 Feb |
3 |
| 2 |
33609419 | Impact of diabetes on promoting the growth of breast cancer. | 2021 May |
1 |
| 3 |
33860870 | PI3K/AKT/mTOR and TLR4/MyD88/NF-κB Signaling Inhibitors Attenuate Pathological Mechanisms of Allergic Asthma. | 2021 Oct |
2 |
| 4 |
33876387 | The Effect of Astaxanthin and Metformin on Oxidative Stress in Granulosa Cells of BALB C Mouse Model of Polycystic Ovary Syndrome. | 2021 Oct |
1 |
| 5 |
34053175 | Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo. | 2021 Jul |
2 |
| 6 |
34630670 | Metformin attenuates H2O2-induced osteoblast apoptosis by regulating SIRT3 via the PI3K/AKT pathway. | 2021 Nov |
2 |
| 7 |
34948457 | Metformin Treatment Attenuates Brain Inflammation and Rescues PACAP/VIP Neuropeptide Alterations in Mice Fed a High-Fat Diet. | 2021 Dec 20 |
2 |
| 8 |
34982428 | The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments. | 2021 Dec |
1 |
| 9 |
31874168 | Hyperactive Akt-mTOR pathway as a therapeutic target for pain hypersensitivity in Cntnap2-deficient mice. | 2020 Mar 15 |
1 |
| 10 |
32523353 | Metformin Suppresses the Proliferation and Promotes the Apoptosis of Colon Cancer Cells Through Inhibiting the Expression of Long Noncoding RNA-UCA1. | 2020 |
1 |
| 11 |
32566257 | Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation. | 2020 |
1 |
| 12 |
32843973 | Diabetes mellitus type 2 drives metabolic reprogramming to promote pancreatic cancer growth. | 2020 Aug |
1 |
| 13 |
32970287 | Metformin downregulates miR223 expression in insulin-resistant 3T3L1 cells and human diabetic adipose tissue. | 2020 Dec |
1 |
| 14 |
33042621 | Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer. | 2020 |
2 |
| 15 |
33099954 | Metformin induces apoptosis of melanoma B16 cells via PI3K/Akt/mTOR signaling pathways. | 2020 Jul-Aug |
3 |
| 16 |
30625338 | Metformin delays AKT/c-Met-driven hepatocarcinogenesis by regulating signaling pathways for de novo lipogenesis and ATP generation. | 2019 Feb 15 |
4 |
| 17 |
30675314 | Metformin selectively targets 4T1 tumorspheres and enhances the antitumor effects of doxorubicin by downregulating the AKT and STAT3 signaling pathways. | 2019 Feb |
1 |
| 18 |
31268904 | Metformin improved oxidized low-density lipoprotein-impaired mitochondrial function and increased glucose uptake involving Akt-AS160 pathway in raw264.7 macrophages. | 2019 Jul 20 |
2 |
| 19 |
31467666 | Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE-/- mice. | 2019 |
3 |
| 20 |
31698699 | Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy. | 2019 Nov 6 |
1 |
| 21 |
29039022 | Metformin Inhibits the Development of L-DOPA-Induced Dyskinesia in a Murine Model of Parkinson's Disease. | 2018 Jul |
1 |
| 22 |
29110119 | Metformin synergistically enhances antitumor activity of cisplatin in gallbladder cancer via the PI3K/AKT/ERK pathway. | 2018 Feb |
1 |
| 23 |
29162538 | Metformin promotes the proliferation and differentiation of murine preosteoblast by regulating the expression of sirt6 and oct4. | 2018 Mar |
1 |
| 24 |
29789508 | Dual Effects of Metformin on Adipogenic Differentiation of 3T3-L1 Preadipocyte in AMPK-Dependent and Independent Manners. | 2018 May 23 |
1 |
| 25 |
30025915 | Metformin suppresses growth and adrenocorticotrophic hormone secretion in mouse pituitary corticotroph tumor AtT20 cells. | 2018 Dec 15 |
2 |
| 26 |
30118770 | A new hypoglycemic mechanism of catalpol revealed by enhancing MyoD/MyoG-mediated myogenesis. | 2018 Sep 15 |
1 |
| 27 |
27803295 | Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis. | 2017 Jan 1 |
1 |
| 28 |
28274614 | Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. | 2017 May 15 |
1 |
| 29 |
28717133 | Insulin upregulates betatrophin expression via PI3K/Akt pathway. | 2017 Jul 17 |
2 |
| 30 |
27334428 | Metformin and gefitinib cooperate to inhibit bladder cancer growth via both AMPK and EGFR pathways joining at Akt and Erk. | 2016 Jun 23 |
1 |
| 31 |
25879666 | Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. | 2015 |
1 |
| 32 |
26467186 | Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions. | 2015 Dec 1 |
2 |
| 33 |
24844651 | Metformin sensitizes prostate cancer cells to radiation through EGFR/p-DNA-PKCS in vitro and in vivo. | 2014 Jun |
1 |
| 34 |
24905037 | Therapeutic potential of metformin in papillary thyroid cancer in vitro and in vivo. | 2014 Aug 5 |
1 |
| 35 |
24053326 | Blockade of reactive oxygen species and Akt activation is critical for anti-inflammation and growth inhibition of metformin in phosphatase and tensin homolog-deficient RAW264.7 cells. | 2013 Dec |
2 |
| 36 |
20857458 | Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cells. | 2011 Apr |
1 |
| 37 |
20097729 | Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice. | 2010 Apr |
1 |
| 38 |
20228137 | Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. | 2010 Jun |
1 |
| 39 |
20363874 | AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation. | 2010 Jun |
1 |
| 40 |
12890675 | Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. | 2003 Oct 10 |
1 |