Metformin

protein kinase AMP-activated catalytic subunit alpha 2 ; Rattus norvegicus







160 Article(s)
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1 33606350 Effects of metformin on the osteogenesis of alveolar BMSCs from diabetic patients and implant osseointegration in rats. 2022 May 1
2 34637881 Antiproliferative effects of metformin in cellular models of pheochromocytoma. 2022 Jan 1 1
3 34689705 ZO-2 favors Hippo signaling, and its re-expression in the steatotic liver by AMPK restores junctional sealing. 2022 Apr 3 1
4 34850372 Decreased efficacy of the ketamine and scopolamine-induced sustained antidepressant-like effects in rats receiving metformin. 2022 Apr 3
5 34994666 AMPK/mTOR-mediated therapeutic effect of metformin on myocardial ischaemia reperfusion injury in diabetic rat. 2022 Jan 7 2
6 35072689 Hyperglycemia Induces Meibomian Gland Dysfunction. 2022 Jan 3 1
7 35156512 Metformin attenuated sepsis-associated liver injury and inflammatory response in aged mice. 2022 Feb 1
8 35278160 Metformin Relieves Bortezomib-Induced Neuropathic Pain by Regulating AMPKa2-Mediated Autophagy in the Spinal Dorsal Horn. 2022 Jul 3
9 35341746 Metformin attenuates early brain injury after subarachnoid hemorrhage in rats via AMPK-dependent mitophagy. 2022 Jul 7
10 35370636 Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney Disease via Inhibition of NLRP3 Inflammasome-Mediated Podocyte Pyroptosis. 2022 2
11 35416184 Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury. 2022 Apr 12 2
12 35449816 Tangshen Decoction Enhances Podocytes Autophagy to Relieve Diabetic Nephropathy through Modulation of p-AMPK/p-ULK1 Signaling. 2022 1
13 35470560 Metformin in nucleus accumbens core reduces cue-induced cocaine seeking in male and female rats. 2022 May 2
14 32990500 Metformin prevents brain injury after cardiopulmonary resuscitation by inhibiting the endoplasmic reticulum stress response and activating AMPK-mediated autophagy. 2021 Feb 3
15 33355497 Metformin protects cardiomyocytes against oxygen-glucose deprivation injury by promoting autophagic flux through AMPK pathway. 2021 Jun 5
16 33439105 Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease. 2021 Apr 1 2
17 33513084 Metformin impairs homing ability and efficacy of mesenchymal stem cells for cardiac repair in streptozotocin-induced diabetic cardiomyopathy in rats. 2021 Apr 1 2
18 33601368 Metformin Inhibits Abdominal Aortic Aneurysm Formation through the Activation of the AMPK/mTOR Signaling Pathway. 2021 1
19 33645317 Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction. 2021 May 1 1
20 33781829 Activation of AMPK restored impaired autophagy and inhibited inflammation reaction by up-regulating SIRT1 in acute pancreatitis. 2021 Jul 15 1
21 33922757 Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats. 2021 Apr 23 3
22 33987977 Metformin Carbon Dots for Promoting Periodontal Bone Regeneration via Activation of ERK/AMPK Pathway. 2021 Jun 1
23 34323699 Evaluation of the effects of metformin as adenosine monophosphate-activated protein kinase activator on spatial learning and memory in a rat model of multiple sclerosis disease. 2021 Sep 1
24 34326272 Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats. 2021 Jul 29 3
25 34381133 Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy. 2021 Aug 11 1
26 34385063 Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway. 2021 Oct 15 1
27 34396450 Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4. 2021 Oct 6
28 34480113 Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury. 2021 Sep 3 1
29 34489707 Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis. 2021 3
30 34555415 Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats. 2021 Dec 1 1
31 34593005 Regulating immune memory and reversing tumor thermotolerance through a step-by-step starving-photothermal therapy. 2021 Sep 30 1
32 34599229 Increased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: effect of AMPK activation. 2021 Oct 1 1
33 34684418 Maternal Metformin Treatment during Gestation and Lactation Improves Skeletal Muscle Development in Offspring of Rat Dams Fed High-Fat Diet. 2021 Sep 28 2
34 34825068 Metformin treatment reverses high fat diet- induced non-alcoholic fatty liver diseases and dyslipidemia by stimulating multiple antioxidant and anti-inflammatory pathways. 2021 Dec 1
35 34975743 Brain Permeable AMP-Activated Protein Kinase Activator R481 Raises Glycaemia by Autonomic Nervous System Activation and Amplifies the Counterregulatory Response to Hypoglycaemia in Rats. 2021 1
36 31423743 Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling. 2020 Feb 1
37 31922237 Metformin attenuates the D‑galactose‑induced aging process via the UPR through the AMPK/ERK1/2 signaling pathways. 2020 Mar 4
38 31971473 Spinal AMP kinase activity differentially regulates phrenic motor plasticity. 2020 Mar 1 3
39 32249610 Metformin arrests the progression of established kidney disease in the subtotal nephrectomy model of chronic kidney disease. 2020 May 1 4
40 32268788 Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. 2020 Jun 2
41 32446297 Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure. 2020 May 23 1
42 32472692 Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy. 2020 Sep 1
43 32480429 Activated FMS-like tyrosine kinase 3 ameliorates angiotensin II-induced cardiac remodelling. 2020 Oct 1
44 32495169 Restoration of β-Adrenergic Signaling and Activity of Akt-Kinase and AMP-Activated Protein Kinase with Metformin in the Myocardium of Diabetic Rats. 2020 May 2
45 32546267 Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway. 2020 Jun 16 4
46 32572457 Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes. 2020 Jun 3 2
47 32621159 Neuroprotective effects of metformin on traumatic brain injury in rats is associated with the AMP-activated protein kinase signaling pathway. 2020 Oct 7
48 32621957 Metformin preferentially provides neuroprotection following cardiac ischemia/reperfusion in non-diabetic rats. 2020 Oct 1 5
49 32639009 Clinically relevant high levels of human C-reactive protein induces endothelial dysfunction and hypertension by inhibiting the AMPK-eNOS axis. 2020 Jul 17 1
50 32750367 Acute administration of metformin prior to cardiac ischemia/reperfusion injury protects brain injury. 2020 Oct 15 1