Protein Name epidermal growth factor receptor
Organism Homo sapiens
Gene ID 1956
Gene Symbol


UniProt P00533 (EGFR_HUMAN), Q504U8 (Q504U8_HUMAN), F2YGG7 (F2YGG7_HUMAN), E9PFD7 (E9PFD7_HUMAN), B7Z2I3 (B7Z2I3_HUMAN), E7BSV0 (E7BSV0_HUMAN)
Relationships Total Number of functionally related compound(s) : 4580
Total Number of Articles : 16269

epidermal growth factor receptor

Gene Summary

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]

  • epidermal growth factor receptor
  • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
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