Metformin

NFE2 like bZIP transcription factor 2 ; Homo sapiens







31 Article(s)
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1 35203060 Metformin alleviates chronic obstructive pulmonary disease and cigarette smoke extract-induced glucocorticoid resistance by activating the nuclear factor E2-related factor 2/heme oxygenase-1 signaling pathway. 2022 Mar 1 1
2 35387349 Metformin Promotes Differentiation and Attenuates H2O2-Induced Oxidative Damage of Osteoblasts via the PI3K/AKT/Nrf2/HO-1 Pathway. 2022 3
3 35588955 Metformin-ROS-Nrf2 connection in the host defense mechanism against oxidative stress, apoptosis, cancers, and ageing. 2022 Aug 3
4 33841656 LASS2 mediates Nrf2-driven progestin resistance in endometrial cancer. 2021 1
5 34197898 Metformin attenuates rotenone-induced oxidative stress and mitochondrial damage via the AKT/Nrf2 pathway. 2021 Sep 4
6 34277866 Efficacy of Photobiomodulation and Metformin on Diabetic Cell Line of Human Periodontal Ligament Stem Cells through Keap1/Nrf2/Ho-1 Pathway. 2021 Apr 2
7 34531248 Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes. 2021 Sep 1
8 31715142 Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway. 2020 Jan 15 4
9 31998447 Metformin Promotes Axon Regeneration after Spinal Cord Injury through Inhibiting Oxidative Stress and Stabilizing Microtubule. 2020 3
10 32048246 Metformin accelerates myelin recovery and ameliorates behavioral deficits in the animal model of multiple sclerosis via adjustment of AMPK/Nrf2/mTOR signaling and maintenance of endogenous oligodendrogenesis during brain self-repairing period. 2020 Jun 3
11 32863218 Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells. 2020 Sep 5
12 32903813 Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway. 2020 1
13 32927432 Metformin suppresses Nrf2-mediated chemoresistance in hepatocellular carcinoma cells by increasing glycolysis. 2020 Sep 14 3
14 33162888 Metformin Ameliorates Gestational Diabetes Mellitus-Induced Endothelial Dysfunction via Downregulation of p65 and Upregulation of Nrf2. 2020 1
15 33200330 Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers. 2020 Nov 16 1
16 33489797 Metformin reverses chemoresistance in non-small cell lung cancer via accelerating ubiquitination-mediated degradation of Nrf2. 2020 Dec 8
17 30229901 Association between glucose-lowering treatment and cancer metastasis among patients with preexisting type 2 diabetes and incident malignancy. 2019 Apr 1 1
18 30803422 Metformin diminishes the unfavourable impact of Nrf2 in breast cancer patients with type 2 diabetes. 2019 Jan 3
19 31091555 Similarities and Distinctions in the Effects of Metformin and Carbon Monoxide in Immunometabolism. 2019 Apr 30 2
20 29549478 Metformin Promotes HaCaT Cell Apoptosis through Generation of Reactive Oxygen Species via Raf-1-ERK1/2-Nrf2 Inactivation. 2018 Jun 1
21 29659168 Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. 2018 Aug 4
22 29772687 Metformin Induces Apoptosis and Alters Cellular Responses to Oxidative Stress in Ht29 Colon Cancer Cells: Preliminary Findings. 2018 May 16 2
23 29921847 Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism. 2018 Oct 3
24 29969038 Metformin Protects against LPS-Induced Intestinal Barrier Dysfunction by Activating AMPK Pathway. 2018 Aug 6 1
25 30333878 Metformin reverses the resistance mechanism of lung adenocarcinoma cells that knocks down the Nrf2 gene. 2018 Nov 5
26 28386373 Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-survivin pathway. 2017 1
27 29230104 Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway. 2017 4
28 26824415 Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway. 2016 Mar 1 1
29 24970682 Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents. 2014 Sep 4
30 23707609 Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways. 2013 Sep 1 6
31 21851178 Meeting report: American Aging Association 40th Annual Meeting, Raleigh, North Carolina, June 3-6, 2011. 2011 Aug 1