Metformin

mitogen-activated protein kinase 3 ; Homo sapiens







35 Article(s)
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1 35561893 Metformin Inhibits Multiple Myeloma Serum-induced Endothelial Cell Thrombosis by Down-Regulating miR-532. 2022 May 10 1
2 33007330 FGFR1 overexpression renders breast cancer cells resistant to metformin through activation of IRS1/ERK signaling. 2021 Jan 1
3 34004440 Metformin prevents BAFF activation of Erk1/2 from B-cell proliferation and survival by impeding mTOR-PTEN/Akt signaling pathway. 2021 Jul 7
4 31789625 Metformin mediated microRNA-7 upregulation inhibits growth, migration, and invasion of non-small cell lung cancer A549 cells. 2020 Apr 2
5 32460900 Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment. 2020 May 27 1
6 32872293 Metformin Derivative HL156A Reverses Multidrug Resistance by Inhibiting HOXC6/ERK1/2 Signaling in Multidrug-Resistant Human Cancer Cells. 2020 Aug 28 1
7 33489797 Metformin reverses chemoresistance in non-small cell lung cancer via accelerating ubiquitination-mediated degradation of Nrf2. 2020 Dec 1
8 30680029 Metformin protects against sevoflurane-induced neuronal apoptosis through the S1P1 and ERK signaling pathways. 2019 Feb 4
9 30911317 Metformin Promotes Neuronal Differentiation via Crosstalk between Cdk5 and Sox6 in Neuroblastoma Cells. 2019 2
10 29380373 Metformin attenuates folic-acid induced renal fibrosis in mice. 2018 Sep 1
11 29399562 Antidiabetic Drug Metformin Protects Neuronal Cells against Quinolinic Acid-Induced Excitotoxicity by Decreasing Intracellular Calcium. 2018 Jan 5
12 29415987 Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth. 2018 Feb 7 2
13 29472557 Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms. 2018 Feb 22 1
14 29549478 Metformin Promotes HaCaT Cell Apoptosis through Generation of Reactive Oxygen Species via Raf-1-ERK1/2-Nrf2 Inactivation. 2018 Jun 1
15 29635803 Stimulating effect of palmitate and insulin on cell migration and proliferation in PNT1A and PC3 prostate cells: Counteracting role of metformin. 2018 Jul 1
16 29760016 Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1. 2018 Jul 20 2
17 30333878 Metformin reverses the resistance mechanism of lung adenocarcinoma cells that knocks down the Nrf2 gene. 2018 Nov 4
18 28927780 Effects of metformin on proliferation and apoptosis of human megakaryoblastic Dami and MEG-01 cells. 2017 Sep 2
19 29344202 Metformin in combination with cisplatin inhibits cell viability and induces apoptosis of human ovarian cancer cells by inactivating ERK 1/2. 2017 Dec 2
20 26804175 Role of Runx2 in IGF-1Rβ/Akt- and AMPK/Erk-dependent growth, survival and sensitivity towards metformin in breast cancer bone metastasis. 2016 Sep 8 1
21 26824324 Metformin inhibits 17β-estradiol-induced epithelial-to-mesenchymal transition via βKlotho-related ERK1/2 signaling and AMPKα signaling in endometrial adenocarcinoma cells. 2016 Apr 19 3
22 27391065 Metformin as a new anti-cancer drug in adrenocortical carcinoma. 2016 Aug 2 1
23 25862373 Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor. 2015 May 22 1
24 26675396 [Research of the influence and mechanism about metformin on the proliferation of differentiated endometrial carcinoma cells]. 2015 Sep 1
25 24396411 Metformin inhibits proliferation of human keratinocytes through a mechanism associated with activation of the MAPK signaling pathway. 2014 Feb 2
26 24419232 Paradoxic effects of metformin on endothelial cells and angiogenesis. 2014 May 1
27 24858012 Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells. 2014 2
28 25245054 Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression. 2014 Dec 2
29 25491250 Analysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer. 2014 1
30 23362830 Metformin induces cytotoxicity by down-regulating thymidine phosphorylase and excision repair cross-complementation 1 expression in non-small cell lung cancer cells. 2013 Jul 1
31 20371705 Metformin, an antidiabetic agent, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro. 2010 Jul 1
32 19414528 Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1. 2009 Aug 1 2
33 19574398 Metformin inhibits aromatase via an extracellular signal-regulated kinase-mediated pathway. 2009 Oct 1
34 16564524 Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture. 2006 Apr 24 1
35 15983226 Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin. 2005 Jul 1