Protein Name hypoxia inducible factor 1 subunit alpha
Organism Homo sapiens
Gene ID 3091
Gene Symbol


UniProt Q16665 (HIF1A_HUMAN), D0VY79 (D0VY79_HUMAN)
Relationships Total Number of functionally related compound(s) : 2152
Total Number of Articles : 5780

hypoxia inducible factor 1 subunit alpha

Gene Summary

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

  • hypoxia-inducible factor 1-alpha
  • ARNT interacting protein
  • PAS domain-containing protein 8
Click to show/hide the synonyms