CPRiL

HIF1A

hypoxia inducible factor 1 subunit alpha

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

• hypoxia-inducible factor 1-alpha
• ARNT interacting protein
• PAS domain-containing protein 8
basic-helix-loop-helix-PAS protein MOP1
class E basic helix-loop-helix protein 78
hypoxia inducible factor 1 alpha subunit
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
hypoxia-inducible factor1alpha
member of PAS protein 1
member of PAS superfamily 1
HIF-1-alpha
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78