| Protein Name | insulin |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3630 |
| Gene Symbol | INS |
| UniProt | P01308 (INS_HUMAN), I3WAC9 (I3WAC9_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
7950
Total Number of Articles : 53676 |
Description |
insulin |
| Gene Summary |
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020] |
| synonyms |
|
| Properties | |