| Protein Name | dipeptidyl peptidase 4 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1803 |
| Gene Symbol | DPP4 |
| UniProt | P27487 (DPP4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
1201
Total Number of Articles : 2927 |
Description |
dipeptidyl peptidase 4 |
| Gene Summary |
The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020] |
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| Properties | |