| Protein Name | insulin like growth factor 1 receptor |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3480 |
| Gene Symbol | IGF1R |
| UniProt | P08069 (IGF1R_HUMAN), C9J5X1 (C9J5X1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
814
Total Number of Articles : 1503 |
Description |
insulin like growth factor 1 receptor |
| Gene Summary |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] |
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