Irinotecan


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788 Functionally related protein(s)
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Protein Name
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UniProt Entry
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Gene Symbol
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Organism
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NCBI Gene ID
# All related compound(s)
#Article(s)
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1 UDP glucuronosyltransferase family 1 member A1 UD11_HUMAN UGT1A1 Homo sapiens 54658 747 410
2 ATP binding cassette subfamily G member 2 (Junior blood group) ABCG2_HUMAN ABCG2 Homo sapiens 9429 1370 134
3 KRAS proto-oncogene, GTPase RASK_HUMAN KRAS Homo sapiens 3845 1547 83
4 epidermal growth factor receptor EGFR_HUMAN EGFR Homo sapiens 1956 4580 80
5 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 68
6 UDP glucuronosyltransferase family 1 member A complex locus - UGT1A Homo sapiens 7361 716 62
7 ATP binding cassette subfamily B member 1 MDR1_HUMAN ABCB1 Homo sapiens 5243 3985 54
8 carboxylesterase 2 EST2_HUMAN CES2 Homo sapiens 8824 433 52
9 vascular endothelial growth factor A VEGFA_HUMAN VEGFA Homo sapiens 7422 4023 33
10 cytochrome P450 family 3 subfamily A member 4 CP3A4_HUMAN CYP3A4 Homo sapiens 1576 3475 31
11 ATP binding cassette subfamily C member 2 MRP2_HUMAN ABCC2 Homo sapiens 1244 684 28
12 solute carrier organic anion transporter family member 1B1 SO1B1_HUMAN SLCO1B1 Homo sapiens 10599 575 27
13 thymidylate synthetase TYSY_HUMAN TYMS Homo sapiens 7298 800 24
14 proteasome 26S subunit, non-ATPase 1 PSMD1_HUMAN PSMD1 Homo sapiens 5707 302 24
15 dihydropyrimidine dehydrogenase DPYD_HUMAN DPYD Homo sapiens 1806 331 22
16 UDP glucuronosyltransferase family 1 member A9 UD19_HUMAN UGT1A9 Homo sapiens 54600 407 22
17 tumor associated calcium signal transducer 2 TACD2_HUMAN TACSTD2 Homo sapiens 4070 201 22
18 erb-b2 receptor tyrosine kinase 2 ERBB2_HUMAN ERBB2 Homo sapiens 2064 2723 21
19 poly(ADP-ribose) polymerase 1 PARP1_HUMAN PARP1 Homo sapiens 142 2571 20
20 glucuronidase beta BGLR_HUMAN GUSB Homo sapiens 2990 859 19
21 ATP binding cassette subfamily C member 1 MRP1_HUMAN ABCC1 Homo sapiens 4363 1125 18
22 caspase 3 CASP3_HUMAN CASP3 Homo sapiens 836 5209 18
23 BCL2 associated X, apoptosis regulator BAX_HUMAN BAX Homo sapiens 581 3031 17
24 carboxylesterase 1 EST1_HUMAN CES1 Homo sapiens 1066 614 17
25 ATP binding cassette subfamily G member 2 (Junior blood group) ABCG2_MOUSE Abcg2 Mus musculus 26357 461 16
26 colony stimulating factor 3 CSF3_HUMAN CSF3 Homo sapiens 1440 955 16
27 checkpoint kinase 1 CHK1_HUMAN CHEK1 Homo sapiens 1111 648 16
28 DNA topoisomerase I TOP1_HUMAN TOP1 Homo sapiens 7150 98 15
29 hypoxia inducible factor 1 subunit alpha HIF1A_HUMAN HIF1A Homo sapiens 3091 2152 15
30 BCL2 apoptosis regulator BCL2_HUMAN BCL2 Homo sapiens 596 4403 14
31 UDP glucuronosyltransferase family 1 member A7 UD17_HUMAN UGT1A7 Homo sapiens 54577 118 14
32 choline phosphotransferase 1 CHPT1_HUMAN CHPT1 Homo sapiens 56994 212 14
33 nuclear factor kappa B subunit 1 NFKB1_HUMAN NFKB1 Homo sapiens 4790 4834 13
34 acetylcholinesterase (Cartwright blood group) ACES_HUMAN ACHE Homo sapiens 43 3471 13
35 B-Raf proto-oncogene, serine/threonine kinase BRAF_HUMAN BRAF Homo sapiens 673 872 13
36 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Q8R427_RAT Abcb1b Rattus norvegicus 24646 765 12
37 ERCC excision repair 1, endonuclease non-catalytic subunit ERCC1_HUMAN ERCC1 Homo sapiens 2067 239 12
38 mutL homolog 1 MLH1_HUMAN MLH1 Homo sapiens 4292 236 11
39 ATM serine/threonine kinase ATM_HUMAN ATM Homo sapiens 472 847 11
40 TNF superfamily member 10 TNF10_HUMAN TNFSF10 Homo sapiens 8743 1439 10
41 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 10
42 topoisomerase (DNA) I TOP1_MOUSE Top1 Mus musculus 21969 54 10
43 tyrosyl-DNA phosphodiesterase 1 TYDP1_HUMAN TDP1 Homo sapiens 55775 208 10
44 glucuronidase, beta BGLR_RAT Gusb Rattus norvegicus 24434 466 10
45 mitogen-activated protein kinase 14 MK14_HUMAN MAPK14 Homo sapiens 1432 3132 10
46 UDP glucuronosyltransferase 1 family, polypeptide A1 UD11_MOUSE Ugt1a1 Mus musculus 394436 79 10
47 ATP binding cassette subfamily C member 4 MRP4_HUMAN ABCC4 Homo sapiens 10257 409 9
48 liver carboxylesterase 1 EST1_RABIT LOC100009551 Oryctolagus cuniculus 100009551 19 9
49 interleukin 6 IL6_MOUSE Il6 Mus musculus 16193 3985 9
50 BCL2 like 1 B2CL1_HUMAN BCL2L1 Homo sapiens 598 1360 9