CPRiL

ABCC1

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

• multidrug resistance-associated protein 1
• ATP-binding cassette transporter variant ABCC1delta-ex13
• ATP-binding cassette transporter variant ABCC1delta-ex13&14
ATP-binding cassette transporter variant ABCC1delta-ex25
ATP-binding cassette transporter variant ABCC1delta-ex25&26
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
LTC4 transporter
glutathione S-conjugate export pump
glutathione-S-conjugate-translocating ATPase ABCC1
leukotriene C(4) transporter
ABC29
ABCC
DFNA77
GS-X
MRP
MRP1