Protein Name B-Raf proto-oncogene, serine/threonine kinase
Organism Homo sapiens
Gene ID 673
Gene Symbol


UniProt P15056 (BRAF_HUMAN)
Relationships Total Number of functionally related compound(s) : 872
Total Number of Articles : 3001

B-Raf proto-oncogene, serine/threonine kinase

Gene Summary

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]

  • serine/threonine-protein kinase B-raf
  • 94 kDa B-raf protein
  • B-Raf proto-oncogene serine/threonine-protein kinase (p94)
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