Protein Name | solute carrier organic anion transporter family member 1B1 |
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Organism | Homo sapiens |
Gene ID | 10599 |
Gene Symbol | SLCO1B1 |
UniProt | Q9Y6L6 (SO1B1_HUMAN), A0A024RAU7 (A0A024RAU7_HUMAN), Q05CV5 (Q05CV5_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
575
Total Number of Articles : 843 |
Description |
solute carrier organic anion transporter family member 1B1 |
Gene Summary |
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009] |
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Properties | |