Protein Name solute carrier organic anion transporter family member 1B1
Organism Homo sapiens
Gene ID 10599
Gene Symbol

SLCO1B1

UniProt Q9Y6L6 (SO1B1_HUMAN), A0A024RAU7 (A0A024RAU7_HUMAN), Q05CV5 (Q05CV5_HUMAN)
Relationships Total Number of functionally related compound(s) : 575
Total Number of Articles : 843
Description

solute carrier organic anion transporter family member 1B1

Gene Summary

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]

synonyms
  • solute carrier organic anion transporter family member 1B1
  • OATP-2
  • liver-specific organic anion transporter 1
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Properties