Protein Name cytochrome P450 family 3 subfamily A member 4
Organism Homo sapiens
Gene ID 1576
Gene Symbol


UniProt P08684 (CP3A4_HUMAN), Q6GRK0 (Q6GRK0_HUMAN)
Relationships Total Number of functionally related compound(s) : 3475
Total Number of Articles : 7032

cytochrome P450 family 3 subfamily A member 4

Gene Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020]

  • cytochrome P450 3A4
  • 1,4-cineole 2-exo-monooxygenase
  • 1,8-cineole 2-exo-monooxygenase
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