Irinotecan

mutL homolog 1 ; Homo sapiens







11 Article(s)
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1 30396964 Patients with hMLH1 or/and hMSH2-deficient Metastatic Colorectal Cancer Are Associated with Reduced Levels of Vascular Endothelial Growth Factor-1 Expression and Higher Response Rate to Irinotecan-based Regimen. 2018 Nov 1
2 30519050 Association of MLH1 single nucleotide polymorphisms with clinical outcomes of first-line irinotecan-based chemotherapy in colorectal cancer. 2018 3
3 28586388 A prospective pilot study of genome-wide exome and transcriptome profiling in patients with small cell lung cancer progressing after first-line therapy. 2017 1
4 23653048 Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan. 2013 Jul 4
5 23724141 MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells. 2013 1
6 19739070 Mismatch repair system decreases cell survival by stabilizing the tetraploid G1 arrest in response to SN-38. 2010 Jun 15 4
7 18941461 Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines. 2008 Nov 18 1
8 17465213 CPT-11 (SN-38) chemotherapy may be selectively applicable to biliary tract cancer with low hMLH1 expression. 2007 Mar-Apr 5
9 20368829 Responsiveness of CPT-11 in respect to hMLH1 and hMSH2 protein expression in the primary colorectal cancer. 2004 Dec 4
10 12209584 Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status. 2002 Sep 1 1
11 12370755 Phosphorylation of chk1 at serine-345 affected by topoisomerase I poison SN-38. 2002 Nov 1