Protein Name thymidylate synthetase
Organism Homo sapiens
Gene ID 7298
Gene Symbol


UniProt P04818 (TYSY_HUMAN), Q53Y97 (Q53Y97_HUMAN)
Relationships Total Number of functionally related compound(s) : 800
Total Number of Articles : 1900

thymidylate synthetase

Gene Summary

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]

  • thymidylate synthase
  • TSase
  • DKCD
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