| Protein Name | thymidylate synthetase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7298 |
| Gene Symbol | TYMS |
| UniProt | P04818 (TYSY_HUMAN), Q53Y97 (Q53Y97_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
800
Total Number of Articles : 1900 |
Description |
thymidylate synthetase |
| Gene Summary |
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017] |
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