| 1 |
34654938 | Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system. | 2022 Feb |
1 |
| 2 |
35396702 | Drug-Drug Interactions and Disease Status Are Associated With Irinotecan-Induced Hepatotoxicity: A Cross-Sectional Study in Shanghai. | 2022 Apr 9 |
1 |
| 3 |
33619631 | Effect of UGT1A1, CYP3A and CES Activities on the Pharmacokinetics of Irinotecan and its Metabolites in Patients with UGT1A1 Gene Polymorphisms. | 2021 Mar |
6 |
| 4 |
32778670 | Effect of drug metabolizing enzymes and transporters in Thai colorectal cancer patients treated with irinotecan-based chemotherapy. | 2020 Aug 10 |
1 |
| 5 |
29504153 | Relevance of CYP3A4*20, UGT1A1*37 and UGT1A1*28 variants in irinotecan-induced severe toxicity. | 2018 Jun |
3 |
| 6 |
23394826 | Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients. | 2013 Nov |
2 |
| 7 |
22764771 | Pharmacologic modulation strategies to reduce dose requirements of anticancer therapy while preserving clinical efficacy. | 2012 Jun |
2 |
| 8 |
23631285 | Predictors of irinotecan toxicity and efficacy in treatment of metastatic colorectal cancer. | 2012 |
1 |
| 9 |
20068078 | A CYP3A4 phenotype-based dosing algorithm for individualized treatment of irinotecan. | 2010 Jan 15 |
8 |
| 10 |
20716241 | Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease. | 2010 Sep |
6 |
| 11 |
20847137 | CYP3A4*16 and CYP3A4*18 alleles found in East Asians exhibit differential catalytic activities for seven CYP3A4 substrate drugs. | 2010 Dec |
5 |
| 12 |
20719167 | Gene Polymorphisms and Chemotherapy in Non-small Cell Lung Cancer. | 2009 Aug 20 |
2 |
| 13 |
17992531 | Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients. | 2008 Aug |
9 |
| 14 |
18248513 | Chemosensitivity determinants of irinotecan hydrochloride in hepatocellular carcinoma cell lines. | 2008 Apr |
1 |
| 15 |
16271446 | Pharmacogenetics of irinotecan metabolism and transport: an update. | 2006 Mar |
1 |
| 16 |
16508919 | Expression of drug pathway proteins is independent of tumour type. | 2006 Jun |
1 |
| 17 |
18666754 | Clinical pharmacokinetics of irinotecan-based chemotherapy in colorectal cancer patients. | 2006 Sep |
1 |
| 18 |
15727486 | Pharmacogenomics of fluorouracil, irinotecan, and oxaliplatin in hepatic metastases of colorectal cancer: clinical implications. | 2005 |
2 |
| 19 |
16123050 | Gefitinib (Iressa) inhibits the CYP3A4-mediated formation of 7-ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin but activates that of 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino]carbonyloxycamptothecin from irinotecan. | 2005 Dec |
1 |
| 20 |
15134628 | Phase 2 trial of BCNU plus irinotecan in adults with malignant glioma. | 2004 Apr |
1 |
| 21 |
15350151 | Drug interactions with St John's wort : mechanisms and clinical implications. | 2004 |
1 |
| 22 |
15523087 | Prediction of irinotecan pharmacokinetics by use of cytochrome P450 3A4 phenotyping probes. | 2004 Nov 3 |
6 |
| 23 |
12570720 | Lessons learned from the irinotecan metabolic pathway. | 2003 Jan |
4 |
| 24 |
14522368 | The role of chemotherapy in brain metastases. | 2003 Oct |
1 |
| 25 |
11901092 | Interaction of irinotecan (CPT-11) and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes. | 2002 Apr |
13 |
| 26 |
11990699 | Influence of phenytoin on the disposition of irinotecan: a case report. | 2002 Feb |
2 |
| 27 |
12019202 | Determination of drug interactions occurring with the metabolic pathways of irinotecan. | 2002 Jun |
2 |
| 28 |
12118026 | Modulation of irinotecan metabolism by ketoconazole. | 2002 Jul 15 |
2 |
| 29 |
12189228 | Effects of St. John's wort on irinotecan metabolism. | 2002 Aug 21 |
1 |
| 30 |
11602529 | A new metabolite of irinotecan in which formation is mediated by human hepatic cytochrome P-450 3A4. | 2001 Nov |
4 |
| 31 |
10815927 | Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans. | 2000 May |
7 |