Protein Name | ATP binding cassette subfamily C member 2 |
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Organism | Homo sapiens |
Gene ID | 1244 |
Gene Symbol | ABCC2 |
UniProt | Q92887 (MRP2_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
684
Total Number of Articles : 922 |
Description |
ATP binding cassette subfamily C member 2 |
Gene Summary |
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008] |
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