Irinotecan

thymidylate synthetase ; Homo sapiens







24 Article(s)
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1 33593942 AraC-FdUMP[10] Is a Next-Generation Fluoropyrimidine with Potent Antitumor Activity in PDAC and Synergy with PARG Inhibition. 2021 Apr 1
2 29861877 SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand. 2018 May 18 1
3 26142736 Association between mismatch repair gene and irinotecan-based chemotherapy in metastatic colon cancer. 2015 Dec 5
4 24156021 Therapeutic enhancement of S-1 with CPT-11 through down-regulation of thymidylate synthase in bladder cancer. 2013 Aug 6
5 22740861 Sequential irinotecan hydrochloride/S-1 for S-1-resistant inoperable gastric cancer: A feasibility study. 2012 Jan 2
6 20628391 UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy. 2010 Aug 10 2
7 20811661 Irinotecan overcomes the resistance to 5-fluorouracil in human colon cancer xenografts by down-regulation of intratumoral thymidylate synthase. 2010 Oct 2
8 19436196 Topoisomerase I expression correlates to response to neoadjuvant irinotecan-based chemoradiation in rectal cancer. 2009 Jul 2
9 19528468 Molecular mechanisms of sequence-dependent antitumor effects of SN-38 and 5-fluorouracil combination therapy against colon cancer cells. 2009 Jun 3
10 18357380 Sequential treatment with SN-38 followed by 5-fluorouracil shows synergistic cytotoxic activity in small cell lung cancer cells. 2008 Apr 8
11 19262706 Thymidylate synthase gene expression in primary tumors predicts activity of s-1-based chemotherapy for advanced gastric cancer. 2007 Sep 7
12 16251201 Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase. 2006 Jan 1
13 16897968 [Antitumor activity and function of S-1, a new oral tegafur-based formulation]. 2006 Jun 2
14 15709193 UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. 2005 Feb 1 2
15 15996331 [Prognostic value of thymidylate synthase, topoisomerase-1 and Ki-67 in advanced colorectal cancer patients on irinotecan and fluorouracil treatment]. 2005 May 1
16 16077970 Thymidylate synthase expression levels: a prognostic and predictive role in advanced colorectal cancer. 2005 Sep 3
17 14962716 Phase I trial of UFT/leucovorin and irinotecan in patients with advanced cancer. 2004 Mar 3
18 15354215 Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer. 2004 Oct 4 2
19 15634630 A phase I-II, dose-escalating trial of ZD9331 in combination with irinotecan (CPT11) in previously pretreated metastatic colorectal cancer patients. 2004 Dec 2
20 12482336 Combination of 5-fluorouracil and irinotecan on modulation of thymidylate synthase and topoisomerase I expression and cell cycle regulation in human colon cancer LoVo cells: clinical relevance. 2002 Nov 1
21 11705873 Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies. 2001 Nov 1
22 10803925 Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs. 2000 2
23 9515577 Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line. 1998 Mar 1 1
24 8664184 Summary of the Second International Conference on Biology, Prevention and Treatment of Gastrointestinal Malignancies. 1995 Sep 1