Protein Name carboxylesterase 1
Organism Homo sapiens
Gene ID 1066
Gene Symbol


UniProt P23141 (EST1_HUMAN)
Relationships Total Number of functionally related compound(s) : 614
Total Number of Articles : 563

carboxylesterase 1

Gene Summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

  • liver carboxylesterase 1
  • acyl coenzyme A:cholesterol acyltransferase
  • brain carboxylesterase hBr1
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