Irinotecan

poly(ADP-ribose) polymerase 1 ; Homo sapiens







20 Article(s)
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Pub. Year
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1 32084420 Enhanced proliferation inhibition and apoptosis in glioma cells elicited by combination of irinotecan and imatinib. 2020 May 5 2
2 30612311 Sensitization of colorectal cancer to irinotecan therapy by PARP inhibitor rucaparib. 2019 Oct 1
3 28443467 Effect of irinotecan on HMGB1, MMP9 expression, cell cycle, and cell growth in breast cancer (MCF-7) cells. 2017 Apr 1
4 26842236 Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors. 2016 Jul 1 1
5 25685067 Treatment with the PARP inhibitor, niraparib, sensitizes colorectal cancer cell lines to irinotecan regardless of MSI/MSS status. 2015 1
6 26257651 Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan. 2015 1
7 26438158 PARP Inhibitors Sensitize Ewing Sarcoma Cells to Temozolomide-Induced Apoptosis via the Mitochondrial Pathway. 2015 Dec 1
8 24215868 Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells. 2014 Feb 28 1
9 23054213 The PARP inhibitor ABT-888 synergizes irinotecan treatment of colon cancer cell lines. 2013 Apr 1
10 23653048 Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan. 2013 Jul 3
11 23913164 TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells. 2013 Oct 2
12 21609311 Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo. 2011 1
13 19208614 The potential role and application of PARP inhibitors in cancer treatment. 2009 1
14 19604089 Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan. 2009 Jul 1
15 18347181 Irinotecan pharmacogenetics: influence of pharmacodynamic genes. 2008 Mar 15 1
16 17431115 S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells. 2007 Apr 1
17 16809434 Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma. 2006 Aug 7
18 12907654 Apoptosis induction in prostate cancer cells and xenografts by combined treatment with Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand and CPT-11. 2003 Aug 1 1
19 11593056 Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo. 2001 Oct 3
20 10100720 Detection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness. 1999 Mar 1