CPRiL

Protein Name	KRAS proto-oncogene, GTPase
Organism	Homo sapiens
Gene ID	3845
Gene Symbol	KRAS
UniProt	P01116 (RASK_HUMAN), L7RSL8 (L7RSL8_HUMAN), A0A024RAV5 (A0A024RAV5_HUMAN), I1SRC5 (I1SRC5_HUMAN)
Relationships	Total Number of functionally related compound(s) : 1547 Total Number of Articles : 3040
Description	KRAS proto-oncogene, GTPase
Gene Summary	This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
synonyms	GTPase KRas K-ras p21 protein KRAS-ENOPH fusion Kirsten rat sarcoma viral oncogene homolog Kirsten rat sarcoma viral proto-oncogene Kras-Enoph1 fusion protein PR310 c-K-ras oncogene c-Kirsten-ras protein cellular c-Ki-ras2 proto-oncogene cellular transforming proto-oncogene oncogene KRAS2 proto-oncogene GTPase transforming protein p21 v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog 'C-K-RAS C-K-RAS CFC2 K-RAS2A K-RAS2B K-RAS4A K-RAS4B K-Ras K-Ras 2 KI-RAS KRAS1 KRAS2 NS NS3 OES RALD Click to show/hide the synonyms
Properties