Irinotecan

ATM serine/threonine kinase ; Homo sapiens







11 Article(s)
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1 35187743 eIF3a-PPP2R5A-mediated ATM/ATR dephosphorylation is essential for irinotecan-induced DNA damage response. 2022 Apr 1
2 35231830 Discovery of novel ataxia telangiectasia mutated (ATM) kinase modulators: Computational simulation, biological evaluation and cancer combinational chemotherapy study. 2022 Apr 5 3
3 33407715 Vulnerability to low-dose combination of irinotecan and niraparib in ATM-mutated colorectal cancer. 2021 Jan 6 3
4 31856090 ATM-Mutated Pancreatic Cancer: Clinical and Molecular Response to Gemcitabine/Nab-Paclitaxel After Genome-Based Therapy Resistance. 2020 Jan 1
5 29963241 Survivin antagonizes chemotherapy-induced cell death of colorectal cancer cells. 2018 Jun 12 1
6 30085332 Radiosensitization by irinotecan is attributed to G2/M phase arrest, followed by enhanced apoptosis, probably through the ATM/Chk/Cdc25C/Cdc2 pathway in p53-mutant colorectal cancer cells. 2018 Oct 2
7 30385821 pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry. 2018 Nov 1
8 27169843 Aberrant BLM cytoplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer. 2017 Mar 1
9 29340025 The novel ATM inhibitor (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan monotherapy. 2017 Dec 19 3
10 27638859 ATM Expression Predicts Veliparib and Irinotecan Sensitivity in Gastric Cancer by Mediating P53-Independent Regulation of Cell Cycle and Apoptosis. 2016 Dec 6
11 24934408 Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy. 2014 Sep 1