Irinotecan

glucuronidase beta ; Homo sapiens







19 Article(s)
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Pub. Year
#Total Relationships
1 33664385 Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity. 2021 Mar 4 1
2 34795594 Berberine Improves Irinotecan-Induced Intestinal Mucositis Without Impairing the Anti-colorectal Cancer Efficacy of Irinotecan by Inhibiting Bacterial β-glucuronidase. 2021 1
3 30831128 Intestinal bacterial β-glucuronidase as a possible predictive biomarker of irinotecan-induced diarrhea severity. 2019 Jul 6
4 26518357 The Inhibitory Effect of Ciprofloxacin on the β-Glucuronidase-mediated Deconjugation of the Irinotecan Metabolite SN-38-G. 2016 May 9
5 25713534 Herbal medicines for the treatment of cancer chemotherapy-induced side effects. 2015 1
6 24195516 Relationship between the expression of CES2, UGT1A1, and GUSB in colorectal cancer tissues and aberrant methylation. 2014 2
7 24439671 Regulation and expression of aberrant methylation on irinotecan metabolic genes CES2, UGT1A1 and GUSB in the in-vitro cultured colorectal cancer cells. 2014 Feb 1
8 25260839 Influence of UGT1A1 gene methylation level in colorectal cancer cells on the sensitivity of the chemotherapy drug CPT-11. 2014 Sep 1
9 23690068 Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity. 2013 Aug 1
10 22535688 Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors. 2012 Aug 3
11 21350582 Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of β-glucuronidase in tumors. 2011 Jun 3
12 19372567 Local enzymatic hydrolysis of an endogenously generated metabolite can enhance CPT-11 anticancer efficacy. 2009 Apr 5
13 18927500 Faecal microflora and beta-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats. 2008 Dec 1
14 16842384 The in vitro metabolism of irinotecan (CPT-11) by carboxylesterase and beta-glucuronidase in human colorectal tumours. 2006 Jul 8
15 12617927 Cancer chemotherapy: a SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug MonoTherapy) strategy. 2003 Mar 10 1
16 14534729 The relative contributions of carboxylesterase and beta-glucuronidase in the formation of SN-38 in human colorectal tumours. 2003 Nov-Dec 7
17 11350876 Modulation of irinotecan-induced diarrhea by cotreatment with neomycin in cancer patients. 2001 May 1
18 10999728 Factors involved in prolongation of the terminal disposition phase of SN-38: clinical and experimental studies. 2000 Sep 1
19 9726089 Pharmacology of irinotecan. 1998 Aug 3