| 1 |
34703007 | Integration of DNA sequencing with population pharmacokinetics to improve the prediction of irinotecan exposure in cancer patients. | 2022 Mar |
1 |
| 2 |
34117512 | Minimal contribution of the hepatic uptake transporter OATP1B1 to the inter-individual variability in SN-38 pharmacokinetics in cancer patients without severe renal failure. | 2021 Sep |
6 |
| 3 |
29034773 | Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1. | 2018 Oct |
2 |
| 4 |
29499902 | Effect of UGT, SLCO, ABCB and ABCC polymorphisms on irinotecan toxicity. | 2018 Dec 14 |
1 |
| 5 |
30360603 | Effects of ABCC2 and SLCO1B1 Polymorphisms on Treatment Responses in Thai Metastatic Colorectal Cancer Patients Treated with Irinotecan-Based Chemotherapy | 2018 Oct 26 |
1 |
| 6 |
28314987 | Cooperative inhibitory effects of uremic toxins and other serum components on OATP1B1-mediated transport of SN-38. | 2017 Apr |
7 |
| 7 |
28397089 | Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects. | 2017 Aug |
2 |
| 8 |
25869015 | Clinical validity of new genetic biomarkers of irinotecan neutropenia: an independent replication study. | 2016 Feb |
1 |
| 9 |
27380948 | Influx transporter variants as predictors of cancer chemotherapy-induced toxicity: systematic review and meta-analysis. | 2016 Jul |
1 |
| 10 |
25611302 | OATP1B1 and tumour OATP1B3 modulate exposure, toxicity, and survival after irinotecan-based chemotherapy. | 2015 Mar 3 |
2 |
| 11 |
26352872 | ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients. | 2015 Dec |
1 |
| 12 |
23921491 | Direct inhibition and down-regulation by uremic plasma components of hepatic uptake transporter for SN-38, an active metabolite of irinotecan, in humans. | 2014 Jan |
3 |
| 13 |
24194565 | OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice. | 2014 Feb |
2 |
| 14 |
21787264 | Pharmacokinetic and pharmacogenetic predictive markers of irinotecan activity and toxicity. | 2011 Dec |
1 |
| 15 |
21892003 | Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study. | 2011 Nov 1 |
2 |
| 16 |
22041697 | [Genetic polymorphisms of SLCO1B1 for drug pharmacokinetics and its clinical implications]. | 2011 |
5 |
| 17 |
18221820 | Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer. | 2009 Jan |
1 |
| 18 |
18998132 | Life-threatening toxicities in a patient with UGT1A1*6/*28 and SLCO1B1*15/*15 genotypes after irinotecan-based chemotherapy. | 2009 May |
2 |
| 19 |
19349540 | Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. | 2009 Jun 1 |
1 |
| 20 |
19390945 | UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients. | 2009 Apr |
2 |
| 21 |
19608554 | Prolonged neutropenia after irinotecan-based chemotherapy in a child with polymorphisms of UGT1A1 and SLCO1B1. | 2009 Dec |
3 |
| 22 |
17766002 | Influence of the organic anion-transporting polypeptide 1B1 (OATP1B1) polymorphisms on irinotecan-pharmacokinetics and clinical outcome of patients with advanced non-small cell lung cancer. | 2008 Jan |
5 |
| 23 |
18558463 | Clinical and pharmacogenetic factors associated with irinotecan toxicity. | 2008 Nov |
1 |
| 24 |
17898662 | Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. | 2007 Oct |
9 |
| 25 |
19356014 | ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan. | 2007 Jan |
1 |
| 26 |
16906022 | Pharmacogenetics of SLCO1B1 gene and the impact of *1b and *15 haplotypes on irinotecan disposition in Asian cancer patients. | 2006 Sep |
7 |
| 27 |
15608127 | Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms. | 2005 Mar |
14 |