Irinotecan

ATP-binding cassette, subfamily B (MDR/TAP), member 1B ; Rattus norvegicus







12 Article(s)
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1 33793796 Possible roles of intestinal P-glycoprotein and cytochrome P450 3A on the limited oral absorption of irinotecan. 2021 Mar 4 5
2 34193275 Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage. 2021 Jul 1 5
3 32349240 Characterization of the Blood-Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma. 2020 Apr 27 1
4 32393425 Effects of cyclosporin A on the pharmacokinetics and toxicities of irinotecan mediated by UGT1A1 in vitro and in vivo. 2020 May 1 1
5 29163158 Shengjiang Xiexin Decoction Alters Pharmacokinetics of Irinotecan by Regulating Metabolic Enzymes and Transporters: A Multi-Target Therapy for Alleviating the Gastrointestinal Toxicity. 2017 1
6 24511364 Curcumin Regulates Colon Cancer by Inhibiting P-Glycoprotein in In-situ Cancerous Colon Perfusion Rat Model. 2013 Jul 8 1
7 21733405 In Situ intestinal perfusion of irinotecan: application to P-gp mediated drug interaction and introduction of an improved HPLC assay. 2011 1
8 19135530 Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats. 2009 Mar 2 4
9 18619980 Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein. 2008 Aug 15 6
10 12817897 Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats. 2003 Jun 4
11 10101137 Possible involvement of P-glycoprotein in biliary excretion of CPT-11 in rats. 1999 Apr 4
12 9750028 Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan (CPT-11), its metabolite SN-38, and its glucuronide: role of canalicular multispecific organic anion transporter and P-glycoprotein. 1998 3