Protein Name poly(ADP-ribose) polymerase 1
Organism Homo sapiens
Gene ID 142
Gene Symbol


UniProt P09874 (PARP1_HUMAN), A0A024R3T8 (A0A024R3T8_HUMAN)
Relationships Total Number of functionally related compound(s) : 2571
Total Number of Articles : 5854

poly(ADP-ribose) polymerase 1

Gene Summary

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

  • poly [ADP-ribose] polymerase 1
  • ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
  • ADP-ribosyltransferase NAD(+)
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