Protein Name dihydropyrimidine dehydrogenase
Organism Homo sapiens
Gene ID 1806
Gene Symbol


UniProt Q12882 (DPYD_HUMAN)
Relationships Total Number of functionally related compound(s) : 331
Total Number of Articles : 1009

dihydropyrimidine dehydrogenase

Gene Summary

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

  • dihydropyrimidine dehydrogenase [NADP(+)]
  • dihydrothymine dehydrogenase
  • dihydrouracil dehydrogenase
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