| Protein Name | dihydropyrimidine dehydrogenase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1806 |
| Gene Symbol | DPYD |
| UniProt | Q12882 (DPYD_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
331
Total Number of Articles : 1009 |
Description |
dihydropyrimidine dehydrogenase |
| Gene Summary |
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
| synonyms |
|
| Properties | |