Protein Name carboxylesterase 2
Organism Homo sapiens
Gene ID 8824
Gene Symbol


UniProt O00748 (EST2_HUMAN)
Relationships Total Number of functionally related compound(s) : 433
Total Number of Articles : 471

carboxylesterase 2

Gene Summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

  • cocaine esterase
  • carboxylesterase 2 (intestine, liver)
  • intestinal carboxylesterase; liver carboxylesterase-2
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